Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits

  • . Alamgeer Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Rashid School of Pharmacy, The University of Faisalabad, Faisalabad
  • Sajid Bashir Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Naveed Mushtaq Faculty of Pharmacy, University of Sargodha, Sargodha
  • Hafeez Ullah Khan Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Nasir Hayat Malik
  • Abdul Qayyum
  • Muhammad Shafeeq ur Rahaman
Keywords: Blood glucose level, ethyl acetate extract, HbA1c, insulin, Teucrium stocksianum Boiss


In the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug gliben-clamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications.


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Ahmad M, Alamgeer, Sharif T. A potential adjunct to insulin: Berberis lycium Royle. Diabetologia Croatica. 2009; 38: 13-18.

Akhtar MS, Nadeem M Haroon-ur-Rashid, Bashir S. Hypoglycaemic activity of different fractions of Berberis aristata root-bark in normal and alloxandiabetic rabbits. Can J App Sci. 2011; 1: 16-28.

Akhtar MS, Khan MA, Malik, MT. Hypoglycemic activity of Alpinia galangal rhizome and its extracts in rabbits. Fitoterapia 2002; 73: 623-28.

Ali N, Shah SWA. Antispasmodic activity of Teucrium stocksianum Boiss. Pak J Pharm Sci. 2011; 24: 171-74.

Andrade-Cetto A, Heinrich M. Mexican Plants with Hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol. 2005; 99: 325-48.

Babu V, Gangadevi T, Subramonia A. Antidiabetic activity of ethanol extract of Cassia kleinii leaf instreptozotocin-induced diabetic rats and isolation of an active fraction and toxicity evaluation of the extract. Indian J Pharmacol. 2003; 35: 290-96.

Cui G, Jing L, Feng Q, Xiao Y, Putheti R. Anti-hyperglycemic Activity of a polysaccharide fraction from Lycium barbarum. Afr J Biomed Res. 2010; 13: 55-59.

Goth MD. Medical pharmacology. 9th ed. Saint Louis, C. V. Mosby Company, 1985, pp 471-80.

Home P, Mant J, Turner C. Management of type 2 diabetes: Summary of updated NICE guidance. Br Med J. 2008; 336: 1306-08.

Khushk MU, Dahot SA, Baloach, Bhutto MA. The evaluation of soybean extracts in alloxan-induced diabetic rabbits. World Appl Sci J. 2010; 8: 22-25.

Knowler WC, Connor BE, Fowler CE. Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002; 346: 393403.

Latha M, Pari L. Effect of an aqueous extract of Scoparia dulcis on blood glucose, plasma insulin and some polyol pathway enzymes in experimental rat diabetes. Braz J Med Biol Res. 2004; 37: 577-86.

McCance DR, Dyer DG, Dunn JA, Bailie KE, Thrope SR, Baynes JW, Lyons TJ. Maillard reaction products and their relation to complications in insulin-dependent diabetes mellitus. J Clin Invest. 1993; 91: 2470-78.

Nishikawa T, Edelstien D, Du XL. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycemic damage. Nature 2000; 404: 78790.

Olajide OA, Awe S, Makinde JM. Purgative effect of the methanol extract of Morinda, Lucida. Fitoterapia 1999; 70: 199-204.

Perfumi M, Arnold N, Tacconi. Hypoglycaemic activity of Salvia fruticosa Mill from Cyprus. J Ethnopharmacol. 1991; 34: 135-40.

Rao BK, Kesavulu MM,Giri R, Appa Rao C. Antidiabetic and hypolipidemic effects of Momordica cymbalaria Hook, fruit powder in alloxan diabetic rats. J Ethnopharmacol. 1999; 67: 10309.

Tomar RS, Sisodia SS. Antidiabetic activity of Annona squamosa L. in experimental induced diabetic rats. Int J Pharm Biol Arch. 2012; 3: 1492-95.

Zaman R, Ahmad M. Evaluation of hepatoprotective effects of Raphanus sativus L. J Biol Sci. 2004; 4: 463-69.

Zimmet P, Alberti KGMM, Shaw J. Global and societal implication of the diabetes epidemic. Nature 2001; 414: 782-87.

How to Cite
Alamgeer, ., M. Rashid, S. Bashir, M. Mushtaq, H. Khan, M. Malik, A. Qayyum, and M. Rahaman. “Comparative Hypoglycemic Activity of Different Extracts of Teucrium Stocksianum in Diabetic Rabbits”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, May 2013, pp. 186-93, doi:10.3329/bjp.v8i2.14519.
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