Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits

  • . Alamgeer Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Rashid School of Pharmacy, The University of Faisalabad, Faisalabad
  • Sajid Bashir Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Naveed Mushtaq Faculty of Pharmacy, University of Sargodha, Sargodha
  • Hafeez Ullah Khan Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Nasir Hayat Malik
  • Abdul Qayyum
  • Muhammad Shafeeq ur Rahaman
Keywords: Blood glucose level, ethyl acetate extract, HbA1c, insulin, Teucrium stocksianum Boiss

Abstract

In the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug gliben-clamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications.

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Published
2013-05-02
How to Cite
Alamgeer, ., M. Rashid, S. Bashir, M. Mushtaq, H. Khan, M. Malik, A. Qayyum, and M. Rahaman. “Comparative Hypoglycemic Activity of Different Extracts of Teucrium Stocksianum in Diabetic Rabbits”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, May 2013, pp. 186-93, doi:10.3329/bjp.v8i2.14519.
Section
Research Articles