CD26/dipeptidyl peptidase IV contributes to tumor metastasis in human lung adenocarcinoma

  • Lei Liu State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Ming Xia Yan State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Fang Yu Zhao State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Jing Li State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Chao Ge State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Qin Geng State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Miao Xin Zhu State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Lei Sun State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Xiang Huo He State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Jin Jun Li State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
  • Ming Yao State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Jiao Tong University School of Medicine, Shanghai
Keywords: CD26/DPPIV, Lung adenocarcinoma, Metastasis, EMT

Abstract

CD26/dipeptidyl peptidase IV (DPPIV) is a 110-kDa trans-membrane ecto-enzyme that has multiple functions in humans. Previously, we established a highly metastatic human lung adenocarcinoma cell line exhibiting epithelial-mesenchymal transition (EMT) by in vivo selection in NOD/SCID mice and performed microarray analysis; we showed that CD26  expression was higher in SPC-A-1sci cells compared to SPC-A-1 parent cells. The effect of CD26 over-expression in lung adenocarcinoma is unclear. In the current study, through Matrigel invasion and metastasis assays and Western blotting assay, we found that CD26 regulated the invasion and metastasis of lung adenocarcinoma cells and that the expression of CD26 correlated with the expression of proteins involved in EMT. The results from human lung adenocarcinoma tissue microarrays showed that CD26 was highly expressed in poorly differentiated lung adenocarcinomas compared to highly differentiated cancers. These results suggest that CD26 has a tumor-promoting function and is a putative prognostic marker for lung adenocarcinoma in patients.

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Published
2013-05-02
How to Cite
Liu, L., M. Yan, F. Zhao, J. Li, C. Ge, Q. Geng, M. Zhu, L. Sun, X. He, J. Li, and M. Yao. “CD26/Dipeptidyl Peptidase IV Contributes to Tumor Metastasis in Human Lung Adenocarcinoma”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, May 2013, pp. 198-06, doi:10.3329/bjp.v8i2.14404.
Section
Research Articles