Evaluation of diuretic activity of Paspalidium flavidum in rats

  • - Alamgeer Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Nasir Hayat Malik Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Sajid Bashir Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Abdul Qayyum Khan Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Naveed Mushtaq Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Muhammad Rashid Department of Pharmacy, University of the Faisalabad
  • Muhammad Akram Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
  • Sadia Samreen Department of Zoology, University of the Punjab, Lahore
Keywords: Diuretic, Furosemide, Paspalidium flavidum, Phytochemical, Rat

Abstract

This study was conducted to investigate the diuretic potential of aqueous methanolic extract of Paspalidium flavidum in rats. The extract at doses of 10, 30 50 and 100 mg/kg was administered intraperitoneally in acute diuretic model. Furosemide (10 mg/kg i.p) was used as standard drug. Total urine volume and urinary excretion of electrolytes were measured. Preliminary phytochemical tests were also performed using standard procedures. The extract exhibiteda significant dose dependent diuretic effect at all the doses when compared to control group. Urinary excretion of sodium was significantly increased by the extract while a significant increase in potassium excretion was only observed at higher doses. Phytochemical analysis illustrated that the extract contained compounds such as alkaloids, saponins, tannins, flavonoids, cardiac glycosides and reducing sugars. It is conceivable therefore that the aqueous methanolic extract of P. flavidum contain certain biologically active compounds that might be responsible for the diuretic activity.

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Author Biography

Muhammad Nasir Hayat Malik, Department of Pharmacy, Faculty of Pharmacy, University of Sargodha, Sargodha
Research Scholar

References

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Published
2013-04-22
How to Cite
Alamgeer, -, M. N. H. Malik, S. Bashir, A. Khan, M. Mushtaq, M. Rashid, M. Akram, and S. Samreen. “Evaluation of Diuretic Activity of Paspalidium Flavidum in Rats”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, Apr. 2013, pp. 177-80, doi:10.3329/bjp.v8i2.14243.
Section
Research Articles