Antimicrobial properties of extracts and compounds isolated from Berberis jaeschkeana

  • Muhammad Alamzeb Phytopharmaceutical and Neutraceutical Research Laboratories, Institute of Chemical Sciences, University of Peshawar, Peshawar
  • Muhammad Rafiullah Khan Phytopharmaceutical and Neutraceutical Research Laboratories, Institute of Chemical Sciences, University of Peshawar, Peshawar
  • Saqib Ali Phytopharmaceutical and Neutraceutical Research Laboratories, Institute of Chemical Sciences, University of Peshawar, Peshawar
  • Syed Qaiser Shah Centre for Nuclear and Molecular Studies, Peshawar 25120
  • Mamoon-Ur- Rashid Phytopharmaceutical and Neutraceutical Research Laboratories, Institute of Chemical Sciences, University of Peshawar, Peshawar
Keywords: Alkaloid, Antimicrobial, Columbamine, Zone of inhibition

Abstract

The present study was undertaken to evaluate the anti microbial properties of Berberis jaeschkeana Schneid Var. jaeschkeana for the first time. The screening of B. jaeschkeana for its phytochemical constituents showed the presence of alkaloids, glycosides, flavonoids, steroids, saponins reducing sugars and terpenoids. Crude ethanolic extract and different fractions showed good antimicrobial properties. Five compounds isolated for the first time from this plant also showed good antimicrobial properties. Columbamine was found to have excellent antimicrobial properties among all the compounds.

Downloads

Download data is not yet available.
Abstract
1561
Download
984 Read
250

References

Edeoga HO, Okwu DE, Mbaebie BO. Phytochemical constituents of some Nigerian medicinal plants. Afr J Biotechnol. 2005; 4: 685-88.

Hill AF. Economic botany: A textbook of useful plants and plant products. 2nd ed. New York, McGraw-Hill Book Company Inc, 1952.

Jafri SMH. Flora of West Pakistan. Nasir E, Ali SI (eds). Vol. 87. Berberidaceae, 1975, pp 1-36.

Lenka G, Jiri D, Radek M. Quaternary protoberberine alkaloids. Phytochemistry 2007; 68: 150-75.

Mohsen I, Hossein H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother Res. 2008; 22: 999-1012.

Radek M, Pavlina S, Dagmar H, Jaromir M, Jiri D, Vladimir S. Palmatine and berberine isolation artifacts. J Nat Prod. 2003; 66: 481-86.

Rashmi A, Rajasekaran, Jagdish P. The genus Berberis Linn.: A Review. Phcog Rev. 2008; 2: 369-85.

Sheng M P, Hsiou Y D, Wen L C, Hang C L. Phenols from the aerial parts of Leonurus sibiricus. Chinese Pharmaceut J. 2006; 58: 35-40.

Tian JH, Yi CC, Yang CW, Chung YC. Chemical constituents from the stems of Mahonia japonica. J Chinese Chem Soc. 2004; 51: 443-46.

Trinh TT, Franke K, Porzel A, Wessjohann L, Tran VS. Quaternary protoberberine alkaloids from Stephania rotunda. J Chem. 2006; 44: 259-64.

Uddin G, Khan AA, Alamzeb M, Ali S, Rashid M, Sadat A, Alam M, Rauf A, Ullah W. Biological screening of ethyl acetate extract of Hedera nepalensis stem. Afr J Pharm Pharmacol. 2012; 6: 2934-37.

Published
2013-02-28
How to Cite
Alamzeb, M., M. Khan, S. Ali, S. Shah, and M.-U.- Rashid. “Antimicrobial Properties of Extracts and Compounds Isolated from Berberis Jaeschkeana”. Bangladesh Journal of Pharmacology, Vol. 8, no. 2, Feb. 2013, pp. 107-9, doi:10.3329/bjp.v8i2.13551.
Section
Research Articles