Molecular docking of viscosine as a new lipoxygenase inhibitor isolated from <i>Dodonaea viscosa</i>

Authors

  • Amir Zada Khan Department of Pharmacy, University of Peshawar, Peshawar 25120
  • Akhtar Mohammad Department of Chemistry, University of Karachi, Karachi 75270
  • Zafar Iqbal Department of Pharmacy, University of Peshawar, Peshawar 25120
  • Itrat Anis Department of Chemistry, University of Karachi, Karachi 75270
  • Muhammad Raza Shah H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270
  • Said Nadeem H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270
  • Muhammad Rabnawaz H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270
  • Adnan Shahidullah Department of Pharmacy, University of Peshawar, Peshawar 25120
  • Humayun Khan Department of Pharmacy, University of Peshawar, Peshawar 25120
  • Inamullah Khan Department of Pharmacy, University of Peshawar, Peshawar 25120

DOI:

https://doi.org/10.3329/bjp.v8i1.13088

Keywords:

Dodonaea viscosa, Lipoxygenase, Molecular docking

Abstract

Viscosine was isolated from Dodonaea viscosa, which showed significant lipoxygenase inhibitory activity (IC50: value 39 ± 0.17). Molecular docking simulations were conducted to explore molecular binding mode, and to help elucidate molecular mechanism behind its significant inhibitory activity. Molecular interactions of viscosine with catalytic triad (His523, His518, Ile875) inside active site of lipoxygenase via hydrogen bonding, seems to be the major factor involved in its significant lipoxygenase inhibitory activity.

Downloads

Download data is not yet available.
Abstract
2022
Download
954 Read
309

References

Ghisalberti EL. Ethnopharmacology and phytochemistry of Dodonaea species. Fitoterapia 1998; 69: 99-113.

Khan I, Nisar M, Shah MR, Shah H, Gilani SN, Gul F, Abdullah SM, Ismail M, Khan N, Kaleem WA, Qayum M, Khan HO. Anti-inflammatory activities of Taxusabietane A isolated from Taxus wallichiana Zucc. Fitoterapea. 2011; 82: 1003-07.

Khan I, Nisar M, Ebad F, Nadeem S, Saeed M, Khan H. Anti-inflammatory activities of Sieboldogenin from Smilax china Linn.: Experimental and computational studies. J Ethnopharmacol. 2009; 121: 17577.

Muhammad A, Anis I, Ali Z, Awadelkarim S, Khan A, Khalid A, Shah MR, Galal A, Khan IA, Choudhary MI. Methylenebissantin: A rare methylene-bridged bisflavonoid from Dodonaea viscosa which inhibits Plasmodium falciparum enoyl-ACP reductase. Bioorganic Med Chem Lett. 2012; 22: 610-12.

Muhammad A, Anis I, Khan A, Marasini BP, Choudhary MI, Shah MR. Biologically Active C-Alkylated Flavonoids from Dodonaea viscosa. Archiv Pharmacol Res. 2012; 35: 431-36.

Utar Z, Majid MIA., Adenan MI., Jamil MFA, Lan TM. Mitragynine inhibits the COX-2 mRNA expression and prostaglandin E2 production induced by lipopolysaccharide in RAW264.7 macrophage cells. J Ethnopharmacol. 2011; 136: 75-82.

van Heerden FR, Viljoen AM, van Wyk BE. The major flavonoid of Dodonaea angustifolia. Fitoterapia 2000; 71: 602-04.

Venkatesh S, Reddy YSR, Ramesh M, Swamy MM, Mahadevan N, Suresh B. Pharmacognostical studies on Dodonaea viscosa Leaves. Afr J Pharm Pharmacol. 2008; 2: 83-88.

Published

2012-12-30

How to Cite

Khan, A. Z., A. Mohammad, Z. Iqbal, I. Anis, M. R. Shah, S. Nadeem, M. Rabnawaz, A. Shahidullah, H. Khan, and I. Khan. “/I>”;. Bangladesh Journal of Pharmacology, vol. 8, no. 1, Dec. 2012, pp. 36-39, doi:10.3329/bjp.v8i1.13088.

Issue

Section

Research Articles