Maintenance therapy with oral etoposide following first-line docetaxel-cisplatin chemotherapy in metastatic non-small cell lung cancer patients

  • Meiyu Fang Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Shengye Wang Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Yabing Zheng Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Xiangmin Kong Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Liyan Gong Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Youhao Qiu Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Yazhen Zhao Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
  • Weimin Mao Zhejiang Thoracic Oncology Institute, Zhejiang Province Cancer Hospital, Zhejiang Cancer Center, Hangzhou
Keywords: Docetaxel, Etoposide, Non-small cell lung cancer

Abstract

The present study evaluated the efficacy and safety of maintenance therapy with oral etoposide following first-line docetaxel-cisplatin chemotherapy in patients with metastatic non-small cell lung cancer. The overall response rate in the docetaxel-cisplatin  phase was 30.4%, with complete response of 0, partial response of 28, stable disease of 39. Maintenance chemotherapy with oral etoposide was given in 67 patients. No complete response  was observed, but 10 patients presented with partial response  and 45 with stable disease . The median time to progression was 5.0 months; median overall survival time was 10 months and the 1-year survival rate was 41% during the maintenance therapy. Therapy with oral etoposide was well tolerated with the hematologic toxicities, fatigue and oral mucositis being the most frequent side effects. Docetaxel-cisplatin  chemotherapy followed by maintenance therapy with oral etoposide was well tolerated and moderately active against metastatic metastatic non-small cell lung cancer.

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Published
2012-09-24
How to Cite
Fang, M., S. Wang, Y. Zheng, X. Kong, L. Gong, Y. Qiu, Y. Zhao, and W. Mao. “Maintenance Therapy With Oral Etoposide Following First-Line Docetaxel-Cisplatin Chemotherapy in Metastatic Non-Small Cell Lung Cancer Patients”. Bangladesh Journal of Pharmacology, Vol. 7, no. 3, Sept. 2012, pp. 192-8, doi:10.3329/bjp.v7i3.11656.
Section
Research Articles