Antiepileptic and central nervous system depressant activity of Sechium edule fruit extract

  • Sayeed Mohammed Firdous Mumtaz Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah, West Bengal
  • Shafique Ahmed Department of Pharmacology, Jamia Hamdard, New Delhi
  • Samiran Dey Department of Pharmaceutical Analysis, Innovative College of Pharmacy, Greater Noida, Uttar Pradesh
Keywords: Antiepileptic, Convulsion, Rota rod, Sechium edule

Abstract

The effect of ethanol extract of fruits of Sechium edule  on antiepileptic and central nervous system (CNS) depressant model was studied in rats. The extract (200 mg/kg body weight, orally) significantly reduced the duration of various phases of convulsions in both MES-induce seizures and in PTZ-induced convulsion. In CNS depressant model, the locomotor activity was also decreased in a dose dependent manner as compared to control group the extract and the rota rod test revealed a significant loss of muscular coordination.

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Published
2012-09-25
How to Cite
Mumtaz, S. M., S. Ahmed, and S. Dey. “Antiepileptic and Central Nervous System Depressant Activity of Sechium Edule Fruit Extract”. Bangladesh Journal of Pharmacology, Vol. 7, no. 3, Sept. 2012, pp. 199-02, doi:10.3329/bjp.v7i3.11275.
Section
Research Articles