In vitro anti-viral effect of fructopyrano-(1→4)-glucopyranose from Radix isatidis on infuenza virus A

  • Qin Sun Department of Pharmaceutics of Chinese Medicine, Luzhou Medical College, Luzhou
  • Pi-Xian Shui Department of Pharmaceutics of Chinese Medicine, Luzhou Medical College, Luzhou
  • Han-Bin Li Henan College of Chinese Medicine, Zhengzhou
  • Si-Jin Yang Affiliated Hospital of Chinese Medicine, Luzhou Medical College, Luzhou
  • Ming-Hua Liu Department of Pharmaceutics of Chinese Medicine, Luzhou Medical College, Luzhou
  • Shi-Jing Zhang Department of Pharmaceutics of Chinese Medicine, Luzhou Medical College, Luzhou
Keywords: Fructopyrano-(1?4)-glucopyranose, Radix Isatidis, influenza virus A, anti-viral effect

Abstract

To investigate the in vitro anti-viral effect of fructopyrano-(1&rarr;4)-glucopyranose (FG) from traditional Chinese medicine Radix isatidis, dog kidney cells (MDCK) were with treated with either FG and then with virus (Group A); virus and then with FG (Group B); or FG and virus simultaneously (Group C). Results showed the in vitro cell protection rate and virus inhibition rate increased significantly with the increase of FG concentration when compared with cells without FG treatment (p<0.01). The anti-viral effect was the best in Group C and that in Group A was superior to that in Group B. FG could exert significant inhibited effect on neuraminidase activity with the IC50 of 0.07 mmol/mL and on hemagglutinin of avian influenza virus with minimum inhibitory concentration of 3.13 mg/mL. Our findings indicate FG can confer obvious antiviral effects on influenza A virus in vitro.

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Published
2012-07-30
How to Cite
Sun, Q., P.-X. Shui, H.-B. Li, S.-J. Yang, M.-H. Liu, and S.-J. Zhang. “In Vitro Anti-Viral Effect of Fructopyrano-(1&Rarr;4)-Glucopyranose from Radix Isatidis on Infuenza Virus A”. Bangladesh Journal of Pharmacology, Vol. 7, no. 3, July 2012, pp. 145-9, doi:10.3329/bjp.v7i3.11228.
Section
Research Articles