Cardiotonic effects of Terminalia arjuna extracts on guinea pig heart in vitro

  • A. M. Mujibul Haq Department of Medicine, Medical College for Women & Hospital, Uttara, Dhaka
  • Md. Mahbubul Huque Department of Medicine, Medical College for Women & Hospital, Uttara, Dhaka
  • Shah Abdur Rahman Chaudhury Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Mohammad Nurul Haque BCSIR, Dhaka
Keywords: Cardiotonic activity, Guinea pig heart, Terminalia arjuna

Abstract

We investigated the effects of fruit and bark extracts of Terminalia arjuna on the rate and contraction of guinea pig heart in vitro. Immediately after killing, the heart was connected to a perfusion apparatus containing oxygenated double-dextrose McWins solution with fresh arjun fruit and bark experimental extracts. The apex of the heart was then connected to a recording drum through a metallic hook and the rate and height (force) of contractions were recorded on a smoked drum. The heights of contraction for fruit extract and bark extract were significantly higher than that for normal saline (p<0.001), while they were significantly lower than that for adrenaline (p<0.01). Addition of verapamil caused a significant blockade in the heights of contraction produced by extracts of T. arjuna (p<0.01), while heart rate was not affected. The cardiotonic effect of T. arjuna was probably mediated through high concentration of Ca++ present in the plant.

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Author Biographies

A. M. Mujibul Haq, Department of Medicine, Medical College for Women & Hospital, Uttara, Dhaka
Professor
Md. Mahbubul Huque, Department of Medicine, Medical College for Women & Hospital, Uttara, Dhaka

Assistant Professor

Shah Abdur Rahman Chaudhury, Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka

Professor

Mohammad Nurul Haque, BCSIR, Dhaka
Principal Scientific Officer

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Published
2012-08-22
How to Cite
Haq, A. M., M. Huque, S. Chaudhury, and M. Haque. “Cardiotonic Effects of Terminalia Arjuna Extracts on Guinea Pig Heart in Vitro”. Bangladesh Journal of Pharmacology, Vol. 7, no. 3, Aug. 2012, pp. 164-8, doi:10.3329/bjp.v7i3.11034.
Section
Research Articles