Anticonvulsant activity of bioflavonoid gossypin

  • Duraisami Rasilingam Department of Pharmacognosy, Nandha College of Pharmacy, Koorapalayam Pirivu, Perundurai Main Road, Erode 638052, Tamil Nadu
  • Srinivasan Duraisamy Department of Pharmacology, Raja Muthiah Dental Collge, Annamalai Universituy, Annamalai Nagar, Chidambaram 608 002. Tamil Nadu
  • Ramaswamy Subramanian Department of Pharmacology, Arupadai Veedu Medical College, Pondicherry 607402
Keywords: Anticonvulsant, Bio-flavonoid, Gossypin, Pentelenetetrazole, Strychnine

Abstract

The anticonvulsant activity of gossypin was investigated by studying the effects on seizures induced by pentelentetrazole, strychnine and maximal electroshock convulsive methods in mice. Gossypin (10 and 20 mg/kg) significantly reduced the duration of convulsion in tonic seizure induced by pentelenetetrazole (95 mg/kg, intraperitoneally). Gossypin (20 mg/kg p.o) significantly reduced the tonic extensor convulsion induced by strychnine and maximum electroshock-induced convulsions. The data obtained suggest that gossypin have anticonvulsant property and may probably be affecting both GABA aminergic and glycine inhibitory mechanism.

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Author Biography

Duraisami Rasilingam, Department of Pharmacognosy, Nandha College of Pharmacy, Koorapalayam Pirivu, Perundurai Main Road, Erode 638052, Tamil Nadu
Professor

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Published
2008-09-17
How to Cite
Rasilingam, D., S. Duraisamy, and R. Subramanian. “Anticonvulsant Activity of Bioflavonoid Gossypin”. Bangladesh Journal of Pharmacology, Vol. 4, no. 1, Sept. 2008, pp. 51-54, doi:10.3329/bjp.v4i1.1081.
Section
Research Articles