Changing patterns of Insulin Resistance in Polycystic Ovary Syndrome

  • R Laila RS & Assistant Professor, Dept. of Gynae & Obs, BIRDEM General Hospital-2, Dhaka
  • N Mahmud Consultant, CARE, BIRDEM General Hospital-2, Dhaka
  • M Nargis Research Officer, BIRDEM, Dhaka
  • TA Chowdhury Professor & Chief Consultant, Dept. of Gynae & Obs, BIRDEM General Hospital-2, Dhaka
Keywords: Polycystic Ovary Syndrome, Insulin Resistance

Abstract

Objective (s):Aim of the study was to explore the changing patterns of insulin resistance in PCOS women.

Methods: The study was conducted at CARE, department of Obstetrics and Gynecology and Biomedical Research Group, BIRDEM hospital. A total number of 103 PCOS women of 15- 36 years were included in the present study. They were grouped into NGT (n=68), IGT (n=30), type 2 DM (n=5) according to nature of glucose tolerance. Fasting and glucose stimulated insulin was measured.

Results: In IGT group, fasting and glucose-stimulated insulin level were higher when compared with NGT, but no difference between type 2 DM and NGT group was found. Insulin-glucose ratio (after glucose load) was significantly lower in type 2 DM when compared with NGT group (p=0.049), but there was no difference of insulin-glucose ratio (fasting) between type 2 DM and NGT group. PCOS with IGT or Type 2 DM women were more insulin resistant than NGT group. (p=0.015, p=0.042 respectively).

Conclusion: Insulin resistance is a major pathophysiologic feature of PCOS with IGT; however â cell secretory defect is associated with type 2 DM in these subjects.

Bangladesh J Obstet Gynaecol, 2014; Vol. 29(2) : 73-77

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Author Biography

R Laila, RS & Assistant Professor, Dept. of Gynae & Obs, BIRDEM General Hospital-2, Dhaka


Published
2016-11-27
How to Cite
Laila, R., Mahmud, N., Nargis, M., & Chowdhury, T. (2016). Changing patterns of Insulin Resistance in Polycystic Ovary Syndrome. Bangladesh Journal of Obstetrics & Gynaecology, 29(2), 73-77. https://doi.org/10.3329/bjog.v29i2.30483
Section
Original Articles