Association of oxytocin receptor gene polymorphisms with autism spectrum disorder in Bengali of Bangladesh population

Authors

  • Mahadia Kumkum Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Lolo Wal Marzan Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Shahin Akter Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Soma Chowdhury Biswas Department of Statistics, Faculty of Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Mahmood Ahmed Chowdhury Institute of Autism and Child Development Centre, Chattogram Maa-O-Shishu General Hospital, Agrabad, Chittagong-4100, Bangladesh
  • Mohammad Afzal Hossain Department of Psychology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh

DOI:

https://doi.org/10.3329/ajmbr.v6i2.48048

Keywords:

autism spectrum disorder (ASD); OXTR; rs53576; polymorphism; BEB population

Abstract

Autism spectrum disorder (ASD) is a group of sex-biased neurodevelopmental disorders characterized by core deficits in social interaction, communication and behaviors. Several lines of evidence indicate that oxytocin signaling through its receptor (OXTR), is vital in a wide range of social behaviors and role of OXTR polymorphism in ASD development has also been established in several populations. Therefore, an attempt was taken to determine whether genetic variations in the oxytocin signaling system contribute to ASD susceptibility in a part of Bangladeshi (BEB) population. We have investigated the role of OXTR polymorphisms (rs53576, rs2254298, rs2228485 and rs237911) in ASD development through PCR-RFLP method, based on case studies. A significant frequency (p = 0.027) for OXTR ‘rs53576AA’ risk genotype was found to be associated with ASD which is consistent with the previous study in Chinese but Caucasian and Japanese population. Besides, no significant association has been found for other OXTR variants (rs2254298, rs2228485 and rs237911) in this study. Understanding of these significant association with ASD development could be open a new clue aimed at clinical marker development for ASD diagnosis and treatment in future.

Asian J. Med. Biol. Res. June 2020, 6(2): 176-186

Downloads

Download data is not yet available.
Abstract
467
PDF
286

Downloads

Published

2020-07-07

How to Cite

Kumkum, M., Marzan, L. W., Akter, S., Biswas, S. C., Chowdhury, M. A., & Hossain, M. A. (2020). Association of oxytocin receptor gene polymorphisms with autism spectrum disorder in Bengali of Bangladesh population. Asian Journal of Medical and Biological Research, 6(2), 176–186. https://doi.org/10.3329/ajmbr.v6i2.48048

Issue

Vol. 6 No. 2 (2020)

Section

Articles

License

Authors who publish with this journal agree to the following terms / The author(s) affirm(s) that:

  1. The manuscript submitted is based on authors own research and is original work.
  2. Authors certify that we all participated in the research work and preparation of the manuscript in a substantive way.
  3. Authors also declare that they have read and approved the manuscript.
  4. Authors further declare that the manuscript has not been published in part or full and is not being submitted or considered for publication in part or full elsewhere.
  5. Any material included in the manuscript does not violate copyright or other rights of anyone. 
  6. Authors  also affirm that the article contains no vilifying or unlawful statements and does not contain material or instructions that might cause harm or injury to the Editor-in-Chief/Editors of the Journal and the public.
  7. Authors assure Asian J. Med. Biol. Res. and the Editor-in-Chief/Editors of the Journals, and hold them harmless from any loss, expense or damage occurred by a claim or suit by a third party for copyright violation, or any suit arising out of any violation of the foregoing warranties as a result of publication of my/our article. 
  8. In consideration of authors manuscript submitted, authors hereby grant Asian J. Med. Biol. Res. unlimited, worldwide, permanent royalty-free, right to publish, use, dispense, license, transmit, display, exhibit, record, store, translate, digitize, broadcast, reproduce and archive, in any format or medium, whether now known or developed hereafter.

All materials related to manuscripts, accepted or rejected, including photographs, original figures etc., will be kept by Asian J. Med. Biol. Res. for one year following the editor’s decision. These materials will then be destroyed.