Association of oxytocin receptor gene polymorphisms with autism spectrum disorder in Bengali of Bangladesh population

  • Mahadia Kumkum Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Lolo Wal Marzan Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Shahin Akter Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Soma Chowdhury Biswas Department of Statistics, Faculty of Sciences, University of Chittagong, Chittagong-4331, Bangladesh
  • Mahmood Ahmed Chowdhury Institute of Autism and Child Development Centre, Chattogram Maa-O-Shishu General Hospital, Agrabad, Chittagong-4100, Bangladesh
  • Mohammad Afzal Hossain Department of Psychology, Faculty of Biological Sciences, University of Chittagong, Chittagong-4331, Bangladesh
Keywords: autism spectrum disorder (ASD); OXTR; rs53576; polymorphism; BEB population

Abstract

Autism spectrum disorder (ASD) is a group of sex-biased neurodevelopmental disorders characterized by core deficits in social interaction, communication and behaviors. Several lines of evidence indicate that oxytocin signaling through its receptor (OXTR), is vital in a wide range of social behaviors and role of OXTR polymorphism in ASD development has also been established in several populations. Therefore, an attempt was taken to determine whether genetic variations in the oxytocin signaling system contribute to ASD susceptibility in a part of Bangladeshi (BEB) population. We have investigated the role of OXTR polymorphisms (rs53576, rs2254298, rs2228485 and rs237911) in ASD development through PCR-RFLP method, based on case studies. A significant frequency (p = 0.027) for OXTR ‘rs53576AA’ risk genotype was found to be associated with ASD which is consistent with the previous study in Chinese but Caucasian and Japanese population. Besides, no significant association has been found for other OXTR variants (rs2254298, rs2228485 and rs237911) in this study. Understanding of these significant association with ASD development could be open a new clue aimed at clinical marker development for ASD diagnosis and treatment in future.

Asian J. Med. Biol. Res. June 2020, 6(2): 176-186

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Abstract
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Published
2020-07-07
How to Cite
Kumkum, M., Marzan, L. W., Akter, S., Biswas, S. C., Chowdhury, M. A., & Hossain, M. A. (2020). Association of oxytocin receptor gene polymorphisms with autism spectrum disorder in Bengali of Bangladesh population. Asian Journal of Medical and Biological Research, 6(2), 176-186. https://doi.org/10.3329/ajmbr.v6i2.48048
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Articles