Omega-3 fatty acids transport through the placenta

  • Ariful Islam Department of Pharmacy, University of Rajshahi, Rajshahi-6205 and Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505
  • Takanori Kodama Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505 and Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505
  • Yui Yamamoto Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505
  • Majid Ebrahimi Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Miyagi 980-8575
  • Hirofumi Miyazaki Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Miyagi 980-8575
  • Yuki Yasumoto Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Miyagi 980-8575
  • Yoshiteru Kagawa Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Miyagi 980-8575
  • Tomoo Sawada Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505
  • Yuji Owada Department of Organ Anatomy, Tohoku University Graduate School of Medicine, Miyagi 980-8575
  • Nobuko Tokuda Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505 and Faculty of Health Sciences, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505
Keywords: Omega-3 fatty acids, FABP3, placenta, fetal development, trophoblast

Abstract

The placenta is a temporary vital organ for sustaining the development of the fetus throughout gestation. Although the fatty acid composition delivered to the fetus is largely determined by maternal circulating levels, the placenta preferentially transfers physiologically important long-chain polyunsaturated fatty acids (LC-PUFAs), particularly omega-3 (n-3) FAs. The precise mechanisms governing these transfers were covered in a veil, but have started to be revealed gradually. Several evidences suggest fatty acid transport proteins (FATPs), placental specific membrane bound fatty acid binding proteins (pFABPpm) and fatty acid translocases (FAT/CD36) involved in LC-PUFAs uptake. Our studies have shown that the placental transfer of omega-3 FAs through the trophoblast cells is largely contributed by fatty acid binding protein 3 (FABP3). Recently there are considerable interests in the potential for dietary omega-3 FAs as a therapeutic intervention for fetal disorders. In fact, prenatal supply of omega-3 FAs is essential for brain and retinal development. Recent findings suggest a potential opportunity of omega-3 FA interventions to decrease the incidence of type 2 diabetes in future generations. In this review, we discuss the molecular mechanism of transportation of omega-3 FAs through the placenta and how omega-3 FAs deficiency/supplementation impact on fetal development.

Asian J. Med. Biol. Res. March 2016, 2(1): 1-8

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Author Biography

Ariful Islam, Department of Pharmacy, University of Rajshahi, Rajshahi-6205 and Department of Organ Anatomy, Yamaguchi University Graduate School of Medicine, Yamaguchi 755-8505


Published
2016-05-15
How to Cite
Islam, A., Kodama, T., Yamamoto, Y., Ebrahimi, M., Miyazaki, H., Yasumoto, Y., Kagawa, Y., Sawada, T., Owada, Y., & Tokuda, N. (2016). Omega-3 fatty acids transport through the placenta. Asian Journal of Medical and Biological Research, 2(1), 1-8. https://doi.org/10.3329/ajmbr.v2i1.27561
Section
Articles