Expression of E-cadherin Gene (CDH1) in Glioblastoma Multiforme

Authors

  • Syeda Noorjahan Karim Associate Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh. https://orcid.org/0009-0005-6646-585X
  • Prasun Biswas Assistant Professor, Department of Pathology, Jamalpur Medical College, Jamalpur, Bangladesh.
  • Shamim Rahman Associate Professor, Department of Pathology, Jahurul Islam Medical College, Kishoreganj, Bangladesh.

DOI:

https://doi.org/10.3329/mediscope.v13i1.87097

Keywords:

E-cadherin gene, CDH1, Glioblastoma

Abstract

Astrocytoma is one of the most common forms of primary brain tumor and glioblastoma is mostly occurred astrocytoma. Due to their invasiveness in the brain parenchyma, they are less amenable to surgical removal and current chemotherapy regimens, with a high mortality rate. Cell adhesion molecule (CAM) E-cadherin (CDH1) downregulation has been implicated in many tumors of higher grade in different systems and organs featuring invasion and metastasis. Cadherins are calcium-binding proteins that promote cell adhesion and tissue homeostasis. The cadherin superfamily includes classical cadherin, protocadherins, desmoglein, desmocollins and others. Classical cadherins include Epithelial (E-cadherin), Neuronal (N-cadherin), placental (P-cadherin) and retinal (R-cadherin), which are the first members of the superfamily to be identified (CDH1, CDH2, CDH3, and CDH4). This study aimed to investigate the level of E-cadherin gene expression in high-grade astrocytoma, that is, glioblastoma multiforme. Therefore, the aim of the study was to find out the level of E-cadherin gene expression in glioblastoma multiforme. In this cross-sectional study, 12 (Twelve) formalin-fixed paraffin-embedded tissues were taken as cases. 3 (Three) non tumorous brain tissue and 1(one) fresh brain tissue were taken as control. Histological features were studied under a light microscope with H& E stain. Expression of the CDH1 gene was analyzed by real-time PCR using the comparative Ct method. The change in E-cadherin expression was measured by fold change in comparison with the control brain tissue. The data was tabulated and a statistical analysis was performed. All tumors showed downregulation of the CDH1 gene in comparison with non-tumorous control tissue. It could be concluded that marked downregulation of the E-cadherin gene occurs with tumors of higher grade due to hypermethylation of the gene promoter.

Mediscope 2026;13(1): 27-33

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Published

2026-02-01

How to Cite

Syeda Noorjahan Karim, Prasun Biswas, & Shamim Rahman. (2026). Expression of E-cadherin Gene (CDH1) in Glioblastoma Multiforme. Mediscope, 13(1), 27–33. https://doi.org/10.3329/mediscope.v13i1.87097

Issue

Vol. 13 No. 1 (2026)

Section

Original Articles

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Copyright (c) 2026 Syeda Noorjahan Karim, Prasun Biswas, Shamim Rahman

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