Etiology & Clinical Pattern of Pancytopenia in Adults in a Tertiary-level Hospital

Authors

  • Md Zahirul Huq Assistant Professor, Department of Medicine, Khulna Medical College Hospital, Khulna, Bangladesh. https://orcid.org/0009-0003-0377-7560
  • Abdullah Al Faroque Associate Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Kamrun Nahar Junior Consultant of Medicine, Dumuria Upazila Health Complex, Khulna, Bangladesh.
  • Kazi Samim Parvez Junior Consultant, Department of Cardiology, Khulna Specialized Hospital, Khulna, Bangladesh.
  • Md Sayfur Rahman Junior Consultant of Medicine, Phultala Upazila Health Complex, Khulna, Bangladesh.
  • Md Forhadul Islam Registrar, Department of Medicine, Khulna Medical College Hospital, Khulna, Bangladesh.
  • Fakir Khaliduzzaman Assistant Professor, Department of Pathology, Gazi Medical College, Khulna, Bangladesh.
  • Md Nazmul Kabir Assistant Professor, Department of Medicine, Khulna Medical College Hospital, Khulna, Bangladesh.

DOI:

https://doi.org/10.3329/mediscope.v12i2.84131

Keywords:

Pancytopenia, Aplastic Anemia, Megaloblastic Anemia

Abstract

Background: Pancytopenia is a hematological condition characterized by the simultaneous reduction of red blood cells, white blood cells and platelets, presenting a wide differential diagnosis.

Objective: This study aimed to analyze the clinical profile and etiological spectrum of pancytopenia patients admitted to the Medicine department of Khulna Medical College Hospital.

Methods: This observational study was conducted in the Department of Medicine at Khulna Medical College Hospital (KMCH), Khulna, Bangladesh, from December 2013 to May 2014. A total of 50 patients with pancytopenia were enrolled through purposive sampling. Patients underwent thorough evaluations including clinical assessments, laboratory investigations and bone marrow examinations. All Statistical analyses were performed using the Statistical Package for the Social Sciences (SPSS) software (version 17).

Results: In this study, aplastic anemia emerged as the most prevalent cause, affecting 56% of patients, followed by megaloblastic anemia (18%), hypersplenism (10%), and malaria (8%). Clinical manifestations primarily included pallor, fatigue, fever and bleeding with significant variations in hematological parameters. Statistical analyses revealed significant differences in absolute neutrophil count (p-value<0.05) and mean corpuscular volume (p-value<0.05) among the various cases.

Conclusion: This study underscores the importance of a comprehensive diagnostic approach to pancytopenia, highlighting regional variations in its etiologies and calling for further investigations to delineate local factors influencing this condition.

Mediscope 2025;12(2): 60-65

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Published

2025-09-16

How to Cite

Md Zahirul Huq, Abdullah Al Faroque, Kamrun Nahar, Kazi Samim Parvez, Md Sayfur Rahman, Md Forhadul Islam, … Md Nazmul Kabir. (2025). Etiology & Clinical Pattern of Pancytopenia in Adults in a Tertiary-level Hospital. Mediscope, 12(2), 60–65. https://doi.org/10.3329/mediscope.v12i2.84131

Issue

Vol. 12 No. 2 (2025)

Section

Original Articles

License

Copyright (c) 2025 Md. Zahirul Huq, Abdullah Al Faroque, Kamrun Nahar, Kazi Samim Parvez, Md. Sayfur Rahman, Md. Forhadul Islam, Fakir Khaliduzzaman, Md. Nazmul Kabir

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