Management of Pain During Propofol Injection Using Intravenous Nitroglycerine

  • Muhammad Sazzad Hossain Associate Professor and Head, Department of Anesthesiology National Institute of ENT, Tejgaon, Dhaka, Bangladesh
  • Mohammad Mamunur Rashid Junior Consultant, Department of Anesthesiology National Institute of ENT, Tejgaon, Dhaka, Bangladesh
  • Md Anisur Rahman Babu Medical officer, Department of Anesthesiology. National Institute of ENT, Tejgaon, Dhaka, Bangladesh
  • Afsana Sultana Medical officer, Department of Anesthesiology. National Institute of ENT, Tejgaon, Dhaka, Bangladesh
  • Md Sirajul Islam Mahfuz Professor of ENT (Unit-3), National Institute of ENT, Tejgaon, Dhaka, Bangladesh
  • Abdur Rahman Associate Professor, Department of Anesthesiology, National Institute of ENT, Tejgaon, Dhaka, Bangladesh
  • Muhammad Alamgir Mandal Associate Professor & Head, Department of Physical Medicine & Rehabilitation. TMSS Medical College & Hospital, Bogura, Bangladesh
Keywords: Nitroglycerine, Propofol, General anesthesia, Pain on propofol injection

Abstract

Background: Propofol is an intravenous (IV) anesthetic agent, can irritate the skin, mucous membrane and venous intima. The main drawback is the pain at injection site following its intravenous injection.

Objectives: This study was performed to evaluate the effect of intravenous nitroglycerine on pain in patients following propofol injection.

Materials and Methods: Eighty adult patients of both sexes, aged 20-50 years, according to American Society of Anesthesiologists (ASA) physical status were divided into two equal groups (n=40) to receive 200 mcg intravenous nitroglycerine diluted in 10 ml saline (group A) and 10 ml normal saline as placebo (group B) at an ambient operating room temperature in a randomized and double blinded fashion to compare the pain-relieving effects of the drugs during propofol injection before the patients lost consciousness. The pain on propofol injection was assessed according to the Mc Crirrick and Hunter scale.

Results: The overall incidence and severity of pain were significantly less in Groups A (nitroglycerine group) than group B (placebo group) (p< 0.05). The incidence of mild and moderate pain in Group A versus group B was 25% vs 45% and 15% vs 30% respectively (p<0.05). The incidence of score '0' (no pain) was higher in Group A (60%) than Group B (25%) (p<0.05).

Conclusion: Pretreatment with 200 mcg nitroglycerine with venous occlusion for one minute is effective pretreatment in alleviating propofol injection pain when compared to placebo.

KYAMC Journal Vol. 10, No.-4, January 2020, Page 202-205

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Abstract
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Published
2020-03-01
How to Cite
Hossain, M. S., Rashid, M. M., Babu, M. A., Sultana, A., Mahfuz, M. S., Rahman, A., & Mandal, M. A. (2020). Management of Pain During Propofol Injection Using Intravenous Nitroglycerine. KYAMC Journal, 10(4), 202-205. https://doi.org/10.3329/kyamcj.v10i4.45720
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Original Articles