Evaluation of Adverse Effects of Sodium Stibogluconate in the Treatment of Visceral Leishmaniasis

Authors

  • Md Abdus Sattar Miah Assistant Professor, Department of Medicine, Pabna Medical College, Pabna
  • Md Abdus Salam Associate Professor, Department of Microbiology, Rajshahi Medical College, Rajshahi
  • Md Azizul Haque Associate Professor, Department of Medicine, Rajshahi Medical College and Hospital, Rajshahi
  • Md Azizul Haque Azad Assistant Professor, Department of Medicine, Rajshahi Medical College and Hospital, Rajshahi
  • Md A K M Enamul Haque Lecturer, Department of Community Medicine, Rajshahi Medical College, Rajshahi
  • Quazi Tarikul Islam Professor, Department of Medicine, Popular Medical College, Dhaka
  • A R M Saifuddin Ekram Professor and Head, Department of Medicine, Rajshahi Medical College and Hospital, Rajshahi

DOI:

https://doi.org/10.3329/kyamcj.v3i1.13659

Keywords:

Sodium, Stibogluconate, Leishmaniasis

Abstract

This descriptive cross-sectional study was carried out in the Department of Medicine, Rajshahi Medical College Hospital to evaluate the adverse effects of sodium stibogluconate in the treatment of visceral leishmaniasis. Out of 30 patients, 19 patients (63.33%) developed abnormalities in ECG. Among them 14 patients (46.67%) developed prolonged QTc, 6 patients (20%) developed Twave inversion and 1 patient (3.33%) developed transient first degree heart block. No patient developed symptomatic arrhythmia. Five patients (16.67%) developed transient raise of bilirubin, 11 patients (36.67%) developed raised SGPT. None of them developed clinical hepatitis. Twenty three patients (76.67%) developed raised serum amylase but none developed clinical pancreatitis. There was no change in renal function. No adverse effects were noted on complete blood count.

DOI: http://dx.doi.org/10.3329/kyamcj.v3i1.13659

KYAMC Journal Vol. 3, No.-1, June 2012 pp.239-243

 

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Published

2013-02-05

How to Cite

Miah, M. A. S., Salam, M. A., Haque, M. A., Azad, M. A. H., Haque, M. A. K. M. E., Islam, Q. T., & Ekram, A. R. M. S. (2013). Evaluation of Adverse Effects of Sodium Stibogluconate in the Treatment of Visceral Leishmaniasis. KYAMC Journal, 3(1), 239–243. https://doi.org/10.3329/kyamcj.v3i1.13659

Issue

Vol. 3 No. 1 (2012)

Section

Original Articles