The Quest for an Effective Dengue Vaccine: Hope or Hype

Authors

  • Fazle Rabbi Chowdhury Associate Professor, Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Quazi Mamtaz Uddin Ahmed Research Affiliate, Department of Tropical Medicine, Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
  • Shrebash Paul Junior Consultant, Medicine, Infectious Disease Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jom.v25i1.70361

Keywords:

Dengue Vaccine

Abstract

Several trials are ongoing to develop a safe and effective vaccine to prevent dengue virus (DENV) infections, especially avoiding the risk of antibody-dependent enhancement. Only three of them (Dengvaxia/CYTTDV, Takeda TAK-003, and NIH TV-003/TV-005) have shown promising results. The issue of ‘hyperendemicity’ and ‘quasi-species the major challenge behind developing a successful vaccine. The overall efficacy of first successful vaccine ‘Dengvaxia’ showed 30.2%–60.8% efficacy with limited protection against DEN 1 and DEN 2. In Bangladesh, since 2019, outbreaks have mostly been caused by DEN 2 and DEN 3, and the trend is predicted to continue for the coming years. TAK-003 gives almost no protection against DEN 3, which is the most notorious serotype encircling Bangladesh. The overall efficacy of this vaccine is 62%, with limited protection against DEN 4. NIH TV-003/TV-005 currently shows more promise with an overall efficacy of 80%. However, we have to wait until June 2024 for the final results. All of these vaccines are safe and effective for travelers. However, for mass vaccination, a country should make a decision based on their prevalent serotypes and the potential serotypes that might cause the next epidemic. To gather these data, a robust serotype- and genotype-based surveillance system and warning system should be in place.

J MEDICINE 2024; 25: 58-67

Downloads

Download data is not yet available.
Abstract
127
PDF
67

Downloads

Published

2024-01-04

How to Cite

Chowdhury, F. R. ., Ahmed, Q. M. U. ., & Paul, S. . (2024). The Quest for an Effective Dengue Vaccine: Hope or Hype. Journal of Medicine, 25(1), 58–67. https://doi.org/10.3329/jom.v25i1.70361

Issue

Vol. 25 No. 1 (2024)

Section

Review Articles

License

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).