Biochemical Status and Cytopathological Profile of Patients Presenting with Multinodular Goiter
Keywords:Multinodular goiter, Hyperthyroidism, Hypothyroidism, Malignancy, FNAC, Scintigram
AbstractBackground: Objective of the study was to evaluate the biochemical status and cytopathological profile in multinodular goiter.
Materials and Methods: 50 patients with multinodular goiter were selected consecutively. Multinodularity was confirmed by ultrasonography and scintiscan of the thyroid gland. Hormonal assays of serum T3, T4 and TSH was done for biochemical status evaluation. Fine needle aspiration cytology (FNAC) was done to evaluate the cytopathological profile of the MNG patients.
Results: The patients had a female preponderance with a male to ratio of 5.25:1. Biochemical status evaluation revealed that sixty percent presented with euthyroid features followed by those of hyperthyroidism (16%). The distribution of hypothyroid, subclinical hypo- and hyper- thyroid patients were equal (8% each). Among the clinical and subclinical hyperthyroids there was Jod Basedow. The cytological profile of multinodular goiter showed that two were malignant (found by open biopsy after surgery) and four had suspicious cytology.
Conclusion: Though relatively benign, risk of malignancy in multinodular goiter should not be undermined and FNAC should be included in the initial diagnostic procedures during work up of a multinodular goiter.
Keyword: Multinodular goiter; Hyperthyroidism; Hypothyroidism; Malignancy; FNAC; Scintigram
J Medicine 2011; 12 : 26-29
How to Cite
LicenseAuthors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).