Proton Pump Inhibitors Usage Among Discharged Patients in a Tertiary Care Hospital- An Observational Study

Authors

  • Akhlak Ahmed Assistant Professor, Department of Medicine, Shaheed Suhrawardy Medical College Hospital, Dhaka
  • Benojeer Akter Assistant Registrar, Department of Medicine, Shaheed Suhrawardy Medical College Hospital, Dhaka
  • Md Mahmudun Naby Registrar, Department of Medicine, Shaheed Suhrawardy Medical College Hospital, Dhaka
  • Md Romanur Rahman Indoor Medical Officer, Department of Medicine, Shaheed Suhrawardy Medical College Hospital, Dhaka
  • Syed Zakir Hossain Associate Professor, Department of Medicine, Shaheed Suhrawardy Medical College Hospital, Dhaka

DOI:

https://doi.org/10.3329/jom.v24i2.67275

Keywords:

Proton pump inhibitors (PPIs), prescription, overuse, indications

Abstract

Background: Proton pump inhibitors (PPI) have reportedly been used in inappropriate clinical settings, often leading to an increased risk of adverse effects, drug interactions, and costs. Aim: The aim of this study was to evaluate the appropriateness of PPI prescription on discharge of patients in medicine ward of a tertiary care hospital in Bangladesh.

Methods: A cross-sectional study was done for 3 months in the department of medicine in a tertiary care hospital to evaluate the indications of PPI use, appropriateness of PPI use and types of PPI prescribed. A total of 107 patients who were prescribed PPI on discharge were enrolled after written informed consent and data were collected in a structured questionnaire.

Results: Among the 107 patients discharged, 64 were males and 43 were females. The mean age was 51.3 ±17.6 (SD) years.Among the study population, 49 were appropriately prescribed PPI and 58 were inappropriately prescribed PPI. Regarding indications, 53.1% received PPI for prevention of anti-platelet induced gastric erosion and 18.9% were prescribed PPI for no apparent reason. Age (p=0.199) and gender (p=0.605) was not significantly associated with the appropriate prescription of PPI.Of the various preparations of PPI prescribed, esomeprazole was prescribed in most of the discharged patients (56%).

Conclusion: this study demonstrates the existence of an over-prescription of PPI. PPI prescription needs to be improved, thereby reducing drug interactions, adverse effects and unnecessary economical expenses.

J MEDICINE 2023; 24(2): 125-130

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Published

2023-07-02

How to Cite

Ahmed, A. ., Akter, B. ., Naby, M. M., Rahman, M. R., & Hossain, S. Z. . (2023). Proton Pump Inhibitors Usage Among Discharged Patients in a Tertiary Care Hospital- An Observational Study. Journal of Medicine, 24(2), 125–130. https://doi.org/10.3329/jom.v24i2.67275

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Original Articles