Vitamin D Level in Healthy Bangladeshi Adults- A Pilot Study

Authors

  • Anil Yadav Department of Medicine (Endocrinology Division), Birat Medical College Teaching Hospital, Biratnagar, Nepal
  • Shahjada Selim Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Tahniyah Haq Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Anil Kumar Shah Department of Medicine (Endocrine Division), Chitwan Medical College, Chitwan, Nepal
  • Md Shahed Morshed Department of Emergency, Kurmitola general hospital, Dhaka, Bangladesh
  • Md Habibul Ghani Department of Internal Medicine, Jinjira 20 Beded Hospital, Dhaka Bangladesh
  • Ibrahim Faisal Department of Endocrinology, Indira Gandhi Memorial Hospital, Kanbaa Aisa Rani Higun, Male, Republic of Maldives
  • Murshed Ahamed khan Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Marufa Mustari Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Mostafa Hasan Rajib Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Md Firoj Hossain Department of Endocrinology Mugda Medical College, Dhaka, Bangladesh
  • MA Hasanat Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Md Fariduddin Department of Endocrinology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jom.v23i2.60631

Keywords:

healthy adults, intact parathormone; vitamin D, 25(OH)D

Abstract

Background: Vitamin D level has profound clinical implications but there is dilemma of optimal vitamin D cut-off level among Bangladeshi population as well in many parts of the world. This study aimed to determine the sufficient level of vitamin D [25 hydroxyvitamin D, 25(OH)D] in relation to intact parathormone (iPTH) in apparently healthy adult volunteers.

Materials and Methods: This cross-sectional study was carried out among 130 apparently healthy adult participants [age (years): 37.57±12.23, mean±SD; m/f: 67/63] in Bangabandhu Sheikh Mujib Medical University, Dhaka. Demographic profile, sunlight exposure and dietary history were taken, physical examinations were done and fasting blood was taken to measure 25(OH)D, iPTH, calcium, albumin and phosphate. Serum 25(OH)D was measured by high performance liquid chromatography whereas iPTH, serum calcium, albumin and phosphate were measured by chemiluminescent Method.

Results: The mean serum 25(OH)D of apparently healthy Bangladeshi adults was 15.44 – 18.44 ng/ml. Vitamin D level was significantly affected by age group [p=0.002], sunlight exposure time [p=0.013] and body surface area [p=0.023] along with sunscreen use [p=0.026]. Serum 25(OH)D had negative predictive association with iPTH [β=-0.220, p=0.012] and positive predictive association with daily sunlight exposure time [β=0.235, p=0.007]. Serum 25(OH)D level above 30 ng/ml was sufficient to keep maximum suppression of iPTH at 54.56 pg/ml by using the quadratic model.

Conclusion: The optimal level of 25(OH)D for apparently healthy adults in Bangladesh is above 30.0 ng/ml.

J MEDICINE 2022; 23: 139-145

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Published

2022-07-24

How to Cite

Yadav, A. ., Selim, S. ., Haq, T. ., Shah, A. K. ., Morshed, M. S., Ghani, M. H. ., Faisal, I. ., khan, M. A. ., Mustari, M. ., Rajib, M. H. ., Hossain, M. F. ., Hasanat, M., & Fariduddin, M. (2022). Vitamin D Level in Healthy Bangladeshi Adults- A Pilot Study. Journal of Medicine, 23(2), 139–145. https://doi.org/10.3329/jom.v23i2.60631

Issue

Vol. 23 No. 2 (2022)

Section

Original Articles

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