The Antibiotic Resistance Profile of Pseudomonas Aeruginosa in a Tertiary Medical Center from Malaysia

Authors

  • Mohd Ali Faiz Medical Officer, Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Chuan Hun Ding Clinical Microbiologist, Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Asrul Abdul Wahab Clinical Microbiologist, Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Mohd Nizam Tzar Clinical Microbiologist, Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Anita Sulong Clinical Microbiologist, Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Kon Ken Wong Clinical Microbiologist, Department of Medical Microbiology & Immunology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
  • Ping Foo Wong Family Medicine Physician, Cheras Baru Health Clinic, Health Department of Federal Territory of Kuala Lumpur and Putrajaya, Ministry of Health of Malaysia, Kampung Cheras Baru, Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.3329/jom.v23i1.57938

Keywords:

Carbapenem, multidrug resistance, piperacillin-tazobactam, polymyxin B, Pseudomonas aeruginosa

Abstract

Background: Pseudomonas aeruginosa is a notorious gram-negative bacterium that has become a globalpublic health concern owing to the emergence of multi- and pandrug-resistant strains. This study sought todetermine the antibiotic susceptibility profile of P. aeruginosa in a tertiary medical center from Malaysia.

Materials and Methods: Each isolate’s identity was confirmed using the VITEK 2 GN kit, and subjectedto antibiotic susceptibility testing using the VITEK 2 AST-N374 card (for testing against piperacillintazobactam,ceftazidime, cefepime, imipenem, meropenem, amikacin, gentamicin and ciprofloxacin) andEtest strips (for testing against doripenem and polymyxin B). Isolates which were not susceptible to >1carbapenem were tested for carbapenemase production using the modified carbapenem inactivationMethod (mCIM).

Results: Out of 102 isolates studied, 64 (62.7%) were fully susceptible to all the antibiotics tested.Twenty-six (25.5%) were resistant to >1 antibiotic from >2 antibiotic classes, and 21 (20.6%) wereresistant to >1 antibiotic from >3 classes. Susceptibility was highest with polymyxin B (100%) and lowestwith piperacillin-tazobactam (64.7%). Carbapenem susceptibility was between 78.4% to 81.4%. Out of 22isolates which were not susceptible to >1 carbapenem, 18 (81.8%) were not susceptible to all threecarbapenems.

Conclusion: More than half of our P. aeruginosa isolates were fully susceptible to all the anti-pseudomonalantibiotics tested. Multidrug-resistant strains accounted for between 20% to 25% of all our P. aeruginosaisolates. Through mCIM testing, carbapenemase production did not appear to be the dominant resistancemechanism.

J MEDICINE 2022; 23: 54-60

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Published

2022-02-03

How to Cite

Faiz, M. A. ., Ding, C. H. ., Wahab, A. A. ., Tzar, M. N. ., Sulong, A. ., Wong, K. K. ., & Wong, P. F. . (2022). The Antibiotic Resistance Profile of Pseudomonas Aeruginosa in a Tertiary Medical Center from Malaysia. Journal of Medicine, 23(1), 54–60. https://doi.org/10.3329/jom.v23i1.57938

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Original Articles