Serum Paraoxonase (Arylesterase) Activity in Chronic Renal Failure
Keywords:Serum paraoxonase (Arylesterase), chronic renal failure, Atherosclerosis
AbstractBackground: Mortality rates are higher among patients with chronic renal failure with a good proportion of this excess burden being attributable to cardiovascular disease. This excess risk is not entirely explained by elevated traditional risk factors. Among the non-traditional risk factors, serum paraoxonase (Arylesterase) activity is an important one.
Materials and Methods: It was a case-control study which included total 127 subjects, 44 were non-dialysis CKD patients, 33 Heamodialysis dependent patients and 50 healthy controls. HDL-C, Apo-A and serum paraoxonase (Arylesterase) activity was estimated and compared with normal control population.
Results: Serum Arylesterase activity, a measure of PON was significantly lower in CRF (on conservative management and on hemodialysis) compared to controls.
Conclusion: Measurement of anti oxidant capacity of HDL-C may improve the predictive accuracy of atherosclerotic coronary artery disease, providing new strategies for the prevention and treatment of accelerated atherosclerosis in chronic renal failure.
Keyword: Serum paraoxonase (Arylesterase); chronic renal failure; Atherosclerosis
J Medicine 2011; 12 : 17-20
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