Milroy’s Disease - The Rarest Cause of Lymphedema

Authors

  • Faizul Islam Chowdhury Associate Professor, Dept. of Medicine, DMCH
  • Ahmedul Kabir Assistant professor, Dept of Medicine, DMCH
  • Jayanta Banik Post-graduate Trainee, Dept. of Medicine, BSMMU
  • Pinaki Paul Registrar, Dept. of Medicine, DMCH
  • Matiur Rahman Medical Officer, Dept. of Medicine, DMCH
  • Shohel Sarkar Post-graduate Trainee, Dept. of Medicine, DMCH
  • Shahimur Pervez Post-graduate Trainee, Dept. of Medicine, DMCH

DOI:

https://doi.org/10.3329/jom.v11i2.5471

Keywords:

Milroy’s Disease, Lymphedema

Abstract

Milroy’s disease is an old term used to describe hereditary congenital lymphedema. It is the rarest of the inherited
lymphedema. The cause is a mutation in the VEGFR3 gene and is inherited in an autosomal dominant manner. This
gene has been mapped to the telomeric part of the chromosome 5q in the region 5q34-q35. It is characterized by
lower limb lymphedema, present at birth or developing soon after. It may be associated with intestinal lymphangiectasia
and cholestasis. Here we report a 57 years old male who had been suffering from bilateral leg swelling since birth and
finally leveled as a case of Milroy’s disease by positive family history and excluding other causes of lymphedema. We
present this case due to the rarity of its occurrence.

Keywords: Milroy’s Disease; Lymphedema

DOI: 10.3329/jom.v11i2.5471

J MEDICINE 2010; 11 : 189-192

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How to Cite

Chowdhury, F. I., Kabir, A., Banik, J., Paul, P., Rahman, M., Sarkar, S., & Pervez, S. (2010). Milroy’s Disease - The Rarest Cause of Lymphedema. Journal of Medicine, 11(2), 189–192. https://doi.org/10.3329/jom.v11i2.5471

Issue

Section

Case Reports