Deep Fungal Infection- An Emerging Problem in Bangladesh
Keywords:Endemic mycoses, histoplasmosis, blastomycosis, mucormycosis, aspergilloma, Bangladesh
AbstractObjective: Invasive deep fungal infections have become a major cause of morbidity and mortality over the past
three decades. Organ transplantation, the use of aggressive chemotherapy and the availability and widespread
use of immunosuppressive treatments for many medical ailments have resulted in large populations of
patients who are at risk of fungal infections. We report our experience to increase awareness of the clinical
spectrum of disseminated fungal infection and its similarity to other infections and malignancy.
Materials and Methods: Case reports from different medical institution for last 6 months were searched through
case registry and recent scientific presentation and publications.
Results: Recently a case of Histoplasmosis was reported in Dhaka Medical College Hospital (DMCH) where
a 57 years old male presented with low grade fever for 3 months, backache followed by progressive
weakness of both lower limbs , there was spastic paraplegia with sensory loss upto the level of D10. An open
biopsy from paravertebral soft tissue showed histopathological features consistent with histoplasmosis. Other
deep fungal infections e.g. pulmonary blastomycoses, mucormycoses and pulmonary aspergilloma were also
reported in DMCH and Bangabandhu Shiekh Mujib Medical University (BSMMU) and RMCH.
Conclusion: As these fungal infections are not commonly encountered in our country and most of the dissemination
has similar clinical features of chronic inflammatory process and malignancy, we need a high index of suspicion to
diagnose with different diagnostic approach. Bangladesh may be experiencing increase load of disseminated fungal
infections and awareness is now very important to explore its underlying aetiology.
Keywords: Endemic mycoses; histoplasmosis; blastomycosis; mucormycosis; aspergilloma; Bangladesh
J MEDICINE 2010; 11 : 170-175
How to Cite
LicenseAuthors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).