Non-traditional Cardiovascular Risk Factors in Chronic Kidney Disease (CKD) and Haemodialysis Dependent patients - A Case Control Study

Authors

  • Ratan Das Gupta Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Muhibur Rahman Professor, Department of Nephrology, Dhaka Medical College.
  • HAM Nazmul Ahasan Professor, Department of Medicine, Dhaka Medical College
  • Md Billal Alam Associate Professor, Department of Medicine, Dhaka Medical College.
  • Md Titu Miah Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Ahmedul Kabir Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Aparna Das Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Md Shahriar Mahbub Post-graduate trainee, Department of Medicine, Dhaka Medical College
  • Mohammad Ashik Imran Khan Post-graduate trainee, Department of Medicine, Dhaka Medical College

DOI:

https://doi.org/10.3329/jom.v11i2.5450

Keywords:

Non-traditional, Cardiovascular, Chronic Kidney Disease

Abstract

Background: Compared with general population mortality rates are 10-20 times higher among patients with end
stage renal disease, with 50% of this excess burden being attributable to cardiovascular disease. This excess risk is not
entirely explained by elevation of traditional risk factors. Elevation of several Non-traditional risk factors associated
with an increased risk for cardiovascular disease in CKD and haemodialysis dependent patients.
Methods: It was a case control study which included total 96 subjects, 48 were non-dialysis CKD patients, 22
Heamodialysis dependent patients and 26 healthy controls. Non-traditional risk factors homocysteine, fibrinogen,
CRP, factor VII activity and haemoglobin estimated and compared with normal control population.
Results: The study revealed that homocysteine , fibrinogen , CRP, factor VII significantly increased and haemoglobin
was significantly low in both non-dialysis CKD and haemodialysis dependent patients in comparison to control group.
Mean homocysteine 15.38, 27.30, 23.76 μmol/L in control, non-dialysis CKD and haemodialysis dependent patient
respectively. Fibrinogen in control , non-dialysis CKD and haemodialysis dependent patient were 180.25 , 264.10 ,
259.59 mg/dl respectively. CRP level in control, non-dialysis CKD and haemodialysis dependent patient were 3.90,
52.59, 17.31 mg/L respectively. Factor VII activity in control was 94.18%, whereas in non-dialysis CKD it was
103.97%, and 106.18 % in haemodialysis dependent patient. haemoglobin was 13.85 gm/dl in control , but in nondialysis
CKD it was 8.08 gm/dl, and in haemodialysis dependent patients 9.46 gm/dl .cardiovascular disease in nondialysis
CKD 54.56% and haemodialysis dependent patients 59.4%
Conclusion: Haemoglobin is low and levels of homocysteine, fibrinogen, CRP, factor-VII activity are increased
among the patients with CKD and haemodialysis dependent patients.

Key words: Non-traditional; Cardiovascular; Chronic Kidney Disease

DOI: 10.3329/jom.v11i2.5450

J MEDICINE 2010; 11 : 108-114

Downloads

Download data is not yet available.
Abstract
1061
PDF
788

Downloads

How to Cite

Gupta, R. D., Rahman, M., Ahasan, H. N., Alam, M. B., Miah, M. T., Kabir, A., Das, A., Mahbub, M. S., & Khan, M. A. I. (2010). Non-traditional Cardiovascular Risk Factors in Chronic Kidney Disease (CKD) and Haemodialysis Dependent patients - A Case Control Study. Journal of Medicine, 11(2), 108–114. https://doi.org/10.3329/jom.v11i2.5450

Issue

Vol. 11 No. 2 (2010)

Section

Original Articles

License

Authors who publish with this journal agree to the following terms:

    1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

    1. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

  1. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).