Non-traditional Cardiovascular Risk Factors in Chronic Kidney Disease (CKD) and Haemodialysis Dependent patients - A Case Control Study

Authors

  • Ratan Das Gupta Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Muhibur Rahman Professor, Department of Nephrology, Dhaka Medical College.
  • HAM Nazmul Ahasan Professor, Department of Medicine, Dhaka Medical College
  • Md Billal Alam Associate Professor, Department of Medicine, Dhaka Medical College.
  • Md Titu Miah Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Ahmedul Kabir Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Aparna Das Assistant Professor, Department of Medicine, Dhaka Medical College.
  • Md Shahriar Mahbub Post-graduate trainee, Department of Medicine, Dhaka Medical College
  • Mohammad Ashik Imran Khan Post-graduate trainee, Department of Medicine, Dhaka Medical College

DOI:

https://doi.org/10.3329/jom.v11i2.5450

Keywords:

Non-traditional, Cardiovascular, Chronic Kidney Disease

Abstract

Background: Compared with general population mortality rates are 10-20 times higher among patients with end
stage renal disease, with 50% of this excess burden being attributable to cardiovascular disease. This excess risk is not
entirely explained by elevation of traditional risk factors. Elevation of several Non-traditional risk factors associated
with an increased risk for cardiovascular disease in CKD and haemodialysis dependent patients.
Methods: It was a case control study which included total 96 subjects, 48 were non-dialysis CKD patients, 22
Heamodialysis dependent patients and 26 healthy controls. Non-traditional risk factors homocysteine, fibrinogen,
CRP, factor VII activity and haemoglobin estimated and compared with normal control population.
Results: The study revealed that homocysteine , fibrinogen , CRP, factor VII significantly increased and haemoglobin
was significantly low in both non-dialysis CKD and haemodialysis dependent patients in comparison to control group.
Mean homocysteine 15.38, 27.30, 23.76 μmol/L in control, non-dialysis CKD and haemodialysis dependent patient
respectively. Fibrinogen in control , non-dialysis CKD and haemodialysis dependent patient were 180.25 , 264.10 ,
259.59 mg/dl respectively. CRP level in control, non-dialysis CKD and haemodialysis dependent patient were 3.90,
52.59, 17.31 mg/L respectively. Factor VII activity in control was 94.18%, whereas in non-dialysis CKD it was
103.97%, and 106.18 % in haemodialysis dependent patient. haemoglobin was 13.85 gm/dl in control , but in nondialysis
CKD it was 8.08 gm/dl, and in haemodialysis dependent patients 9.46 gm/dl .cardiovascular disease in nondialysis
CKD 54.56% and haemodialysis dependent patients 59.4%
Conclusion: Haemoglobin is low and levels of homocysteine, fibrinogen, CRP, factor-VII activity are increased
among the patients with CKD and haemodialysis dependent patients.

Key words: Non-traditional; Cardiovascular; Chronic Kidney Disease

DOI: 10.3329/jom.v11i2.5450

J MEDICINE 2010; 11 : 108-114

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How to Cite

Gupta, R. D., Rahman, M., Ahasan, H. N., Alam, M. B., Miah, M. T., Kabir, A., Das, A., Mahbub, M. S., & Khan, M. A. I. (2010). Non-traditional Cardiovascular Risk Factors in Chronic Kidney Disease (CKD) and Haemodialysis Dependent patients - A Case Control Study. Journal of Medicine, 11(2), 108–114. https://doi.org/10.3329/jom.v11i2.5450

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