Anti-hyperglycemic Effect of <i>Stephania Glabra</i> Tubers in Alloxan Induced Diabetic Mice

Authors

  • Deepak Kumar Semwal Department of Chemistry, University of Garhwal, Srinagar, U.K. 246174, India
  • Usha Rawat Department of Chemistry, University of Garhwal, Srinagar, U.K. 246174, India
  • Ruchi Badoni Department of Chemistry, University of Garhwal, Srinagar, U.K. 246174, India
  • Ravindra Semwal Department of Pharmaceutics, K.N. Modi, Institute of Pharmaceutical Education and Research, Modi Nagar, India
  • Randhir Singh Department of Pharmaceutical Sciences & Drug Research, Faculty of Medicine, Punjabi University, Patiala, P.B., 147002, India

DOI:

https://doi.org/10.3329/jom.v11i1.4262

Keywords:

Stephania glabra, Menispermaceae, hydroxypalmatine, alloxan, glibenclamide, hypoglycemic activity

Abstract

Different doses of ethanolic extract of Stephania glabra tuber were evaluated for antihyperglycemic activity in alloxan induced diabetic mice. The oral administration of 100, 200 and 500 mg/kg body weight showed significant hypoglycemic activity. Glibenclamide (oral hypoglycemic agent, 25 mg/kg, p.o.) has been used as standard.

Key words: Stephania glabra, Menispermaceae, hydroxypalmatine, alloxan, glibenclamide, hypoglycemic activity

DOI:10.3329/jom.v11i1.4262

J Medicine 2010: 11: 17-19

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How to Cite

Semwal, D. K., Rawat, U., Badoni, R., Semwal, R., & Singh, R. (2010). Anti-hyperglycemic Effect of <i>Stephania Glabra</i> Tubers in Alloxan Induced Diabetic Mice. Journal of Medicine, 11(1), 17–19. https://doi.org/10.3329/jom.v11i1.4262

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Original Articles