Microangiopathic Hemolytic Anemia: A Rare Clue to Diagnose Bone Marrow Metastatic Gastric Adenocarcinoma

Authors

  • Md Shahriar Siddiki Indoor Medical Officer, Department of Medicine, Dhaka Medical College Hospital (DMCH), Dhaka
  • Nur Alam Indoor Medical Officer, Department of Medicine, Dhaka Medical College Hospital (DMCH), Dhaka
  • Istiuqe Ahmed Indoor Medical Officer, Department of Medicine, Dhaka Medical College Hospital (DMCH), Dhaka
  • Md Kamrul Hasan Patwari Indoor Medical Officer, Department of Medicine, Dhaka Medical College Hospital (DMCH), Dhaka
  • Md Habibur Rahman Indoor Medical Officer, Department of Medicine, Dhaka Medical College Hospital (DMCH), Dhaka
  • Rajib Bhowmic Assistant Registrar, Department of Medicine, DMCH, Dhaka
  • Minahj Uddin Bhuiyan Registrar. Department of Medicine, DMCH, Dhaka
  • Sarmistha Biswas Associate professor, Department of Medicine, DMCH, Dhaka
  • Md Faizul Islam Chowdhury Professor, Department of Medicine, DMCH, Dhaka

DOI:

https://doi.org/10.3329/jom.v20i2.42012

Keywords:

Microangiopathic hemolytic anemia (MAHA); gastric adenocarcinoma; bone marrow metastasis.

Abstract

Microangiopathic Hemolytic Anemia (MAHA) is a hematological condition which is very rare for the primary presentation of a gastric adenocarcinoma with bone marrow metastases. When it emerges as initial findings in a previously undetected case of malignancy, the diagnosis is often missed and results in inappropriate management. Carcinoma stomach associated with MAHA is generally having fulminant course. This is a case report of a 30-year-old male who presented with widespread bone marrow infiltration along with Coomb’s negative haemolytic anemia, thrombocytopenia and schistocytes in peripheral blood typical of MAHA. The combination of MAHA and bone marrow infiltration in gastric adenocarcinoma is a very rare entity. When the cause of progressive MAHA is unknown, the possibility of cancer-associated MAHA must be excluded by performing additional tumor workup, including the detection of tumor markers, Endoscopy of upper GIT, colonoscopy, bone marrow examinations, and PET-CT or bone scans.

J MEDICINE JUL 2019; 20 (2) : 102-105

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Published

2019-06-27

How to Cite

Siddiki, M. S., Alam, N., Ahmed, I., Patwari, M. K. H., Rahman, M. H., Bhowmic, R., Bhuiyan, M. U., Biswas, S., & Chowdhury, M. F. I. (2019). Microangiopathic Hemolytic Anemia: A Rare Clue to Diagnose Bone Marrow Metastatic Gastric Adenocarcinoma. Journal of Medicine, 20(2), 102–105. https://doi.org/10.3329/jom.v20i2.42012

Issue

Section

Case Reports