Clinical Value of Serum Cancer Antigen 19-9 as a Tumor Screening Marker among Healthy Individuals

Authors

  • Prodip Kumar Biswas Associate Professor of Medicine, Dhaka Medical College, Dhaka
  • Md Hafiz Sardar Professor of Medicine, Dhaka Medical College, Dhaka
  • Gopal Chandra Saha Assistant Professor, Department of Radiology and Imaging, Institute of Child and Mother Health, Dhaka
  • Mohammed Shahadat Hossain Assistant Professor of Medicine, OSD, DGHS. Attached to Faridpur Medical College, Faridpur
  • Mohammad Motlabur Rahman Associate Professor of Medicine, Dhaka Medical College, Dhaka
  • Mostofa Kamal Chowdhury Assistant Professor, Department of Palliative Medicine, Centre for Palliative Care, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Tushit Paul Post graduate trainee, Department of Medicine, Dhaka Medical College, Hospital, Dhaka

DOI:

https://doi.org/10.3329/jom.v20i2.42009

Keywords:

Tumor marker, CA 19-9, Malignancy

Abstract

Background: Serum tumor markers are convenient, non-invasive, acceptable to patients and play an important role as an ancillary tumor diagnostic tool. CA 19-9 has become a common tumor marker, specific for digestive system tumors. The study was carried out to determine the value of CA 19-9 as a tumor screening marker among healthy individuals.

Materials and Methods: This study had been carried in Dhaka Medical college Hospital from January 2016 to January 2018. The serum CA 19-9 level was detected using a microsome luminescence method. Individuals with high CA 19-9 levels underwent further examination, including routine fecal testing, thoracic and abdominal computed tomography (CT) scan, gastroscopy, and colonoscopy. These individuals had regular follow-up examinations.

Results: Over a 3-year period, the serum CA19-9 levels of 960 healthy individuals were estimated. The CA 19-9 level of 15 individuals was positive (positive rate: 1.56%), including 7 men (7/699; 1.001%) and 8 women (8/261; 3.06%). There was a significant difference between males and females (p<0.01), The overall tumor detection rate was 0.72% (7/960) including 6/699 men (0.85%) and 1/261 women (0.38%).

Conclusion: Therefore, elevated CA 19-9 level can be used to assist in the diagnosis malignancy.

J MEDICINE JUL 2019; 20 (2) : 92-94

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Published

2019-06-27

How to Cite

Biswas, P. K., Sardar, M. H., Saha, G. C., Hossain, M. S., Rahman, M. M., Chowdhury, M. K., & Paul, T. (2019). Clinical Value of Serum Cancer Antigen 19-9 as a Tumor Screening Marker among Healthy Individuals. Journal of Medicine, 20(2), 92–94. https://doi.org/10.3329/jom.v20i2.42009

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Original Articles