Predictors of Morbidity & Mortality in Organophosphorus Poisoning: A Case Study in Rural Hospital of Karnataka
Keywords:Organophosphorus compounds, Achcholiesterase, Pseudocholiesterase, Respiratory failure, Atropine.
Organophosphorous pesticides poisoning can result from occupational, accidental or intentional exposure. Clinical manifestations include cholinergic syndromes, central nervous system and cardiovascular disorders Death is usually due to cardiovascular& respiratory failure.
Material & methods: This case series was conducted in department Medicine AIMS, Bangalore from July 2013 to June 2014. Detailed history & clinical examination was done. Diagnosis of OP poisoning was based on clinical features, history of exposure to a known OP compound and low serum Achcholiesterase & pseudocholiesterase activity.
Results: Out of one thirty three, one hundred and thirty (82.66%) patients ingested the compound, 23 (7.6%) & only three patients had dermal / inhaled exposure while spraying pesticides in rice fields. In our study female to male ratio in was 1: 3.2, age ranged from 13 to 50 years with mean age was 31.5 years. Acute complications were frequently noted and were related to morbidity & mortality. Most consistent clinical symptoms were miosis 93.6%, increased salivation 86.4%, anxiety and restlessness 82.7%, bronchospam 78.1% and incontinence in 58%.
Conclusion: In OP acute complications are seen more frequently and are related to mortality & morbidity. The importance of rapid diagnosis, early and effective treatment should not be overlooked because patients who receive early& effective treatment generally will do better and have less complication and severity of poisoning.
J MEDICINE January 2016; 17 (1) : 3-7
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