Cardiovascular Disease in Women with Chronic Renal Failure
Keywords:Lipid profile, chronic renal failure, cardiovascular disease
Objective: Patients with chronic renal failure have high burden of cardiovascular morbidity and mortality. This study was carried out to investigate the development of cardiovascular disease in chronic renal failure among female patients on dialysis treatment in Nigeria.
Materials and Methods: A total of 40 adult female subjects participated in this study. 20 of them were apparently healthy and served as control group while the rest 20 were female patients with chronic renal failure (CRF) on dialysis treatment. Fasting blood samples were collected and their lipid profile, Total Cholesterol (TC), Triglyceride (TG), High Density Lipoprotein Cholesterol (HDL-C), Low Density Lipoprotein Cholesterol (LDL-C), and Very Low Density Lipoprotein Cholesterol (VLDL-C) were estimated using enzymatic methods. The percentages of these parameters in circulation were obtained. The cardiovascular risk ratios (TC/HDL-C and LDL-C/HDL-C) were calculated.
Result: The lipid profile of the chronic renal failure patients (TC 5.70±0.80mmol/l, TG 1.46±0.40mmol/l, LDL-C 3.50±0.2mmol/l, and VLDL-C 0.67±0.2mmol/l) were significantly higher (p<0.05) than that of control group (TC 4.03±0.13mmol/l, TG 1.10± 0.3mmol/l , LDL-C 1.85±0.5mmol/l, and VLDL-C 0.50± 0.01mmol/l) except HDL-C. HDL-C of the CRF patients (1.40±0.2mmol/l) was significantly lower (p<0.05) than that of healthy women (HDL-C 1.70± 0.04mmol/l). These depict no difference in the percentage of VLDL-C & TG in circulation between the control (VLDL C 5% and TG 45%) and chronic renal failure patients (VLDL C 5% and TG 44%). In CRF group, it was observed that 28% of the total plasma lipid (12.73mmol/l) was LDL-C but in healthy women, percentage of LDL-C in circulation (out of 9.18mmol/l) was 20%. It was also observed that 11% of the total plasma lipid (12.73mmol/l) in CRF patients was HDL-C but in healthy subjects, the percentage of HDL-C in circulation (out of 9.18mmol/l) was 19%. The cardiovascular risk indices (TC/HDL-C and LDL-C/HDL-C) of the CRF patients (TC/HDL-C 3.91±0.24 and LDL-C/HDL-C 2.50±0.01) were significantly higher (p<0.05) than those of the healthy subjects (TC/HDL-C 2.40±0.09, LDL-C/HDL-C 1.10±0.08).
Conclusion: These results indicate that chronic renal failure is a risk factor to development of cardiovascular disease in female patients on dialysis.
J MEDICINE 2015; 16 : 14-17
How to Cite
LicenseAuthors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).