Pattern of Stroke among Adult (A-MMD) and Childhood Onset (C-MMD) Moyamoya Disease

Authors

  • ATM Hasibul Hasan Assistant Professor, Department of Neurology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Kazi Mohibur Rahman Professor, Department of Interventional Neurology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Sharif Uddin Khan Professor, Department of Neurology, National Institute of Neurosciences & Hospital, Dhaka, Bangladesh
  • Shakir Hussain Hakim Professor & Deputy Head Interventional Neuroradiology, Co-director, International Fellowship Program, Department of Neuroradiology, University of Zürich, Switzerland
  • Mansur Habib Professor and Former Head, Department of Neurology, Dhaka Medical College & Hospital, Dhaka, Bangladesh
  • Md Badrul Alam Joint Director & Professor of Neurology, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh
  • Quazi Deen Mohammad Director & Professor of Neurology, National Institute of Neurosciences and Hospital, Dhaka, Bangladesh

DOI:

https://doi.org/10.3329/jninb.v6i2.50747

Keywords:

Stroke; moyamoya disease; adult onset-moyamoya disease; childhood onset-moyamoya disease

Abstract

Background: Though relatively rare, moyamoya disease (MMD) may have varied presentation in different age group. Different stroke types are major presentation of this enigmatic disease. Objective: The aim of this study was to compare the stroke subtypes among adult (A-MMD) and childhood onset (C-MMD) patients with Moyamoya disease (MMD).

Methodology: This was a hospital based observational study, conducted in the department of Neurology, Dhaka Medical College Hospital, Bangabandhu Sheikh Mujib Medical University and National Institute of Neurosciences and Hospital, Dhaka, Bangladesh in between July, 2007 to June, 2016. Sample size included 36 children and 14 adult patients of MMD presenting with either ischemic or hemorrhagic stroke, within one month of the index event.

Result: Majority of participants were below 10 years of age with a mean age at onset of 16.56(±10.6) years. There was a female predominance. Patients younger than 20 years, presented mostly with ischemic stroke (32 versus 4 patients); whereas those above 20 years of age presented mostly with hemorrhagic stroke (6 versus 8 patients). The difference was statistically significant (p value = 0.006). Large artery infarct (15) and hemodynamic infarct (17) were common among patients in children; whereas intracerebral hemorrhage (dICH, lICH, IVH among 3, 4 and 1 patients respectively) was frequent (8) among the adult (p value = 0.006).

Conclusion: While different pattern of ischemic stroke is common among children with MMD, the adults present mostly with hemorrhagic stroke subtypes.

Journal of National Institute of Neurosciences Bangladesh, 2020;6(2): 87-90

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Published

2020-12-13

How to Cite

Hasan, A. H., Rahman, K. M., Khan, S. U., Hakim, S. H., Habib, M., Alam, M. B., & Mohammad, Q. D. (2020). Pattern of Stroke among Adult (A-MMD) and Childhood Onset (C-MMD) Moyamoya Disease. Journal of National Institute of Neurosciences Bangladesh, 6(2), 87–90. https://doi.org/10.3329/jninb.v6i2.50747

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Section

Original Research Articles