Therapeutic effectiveness of Glyceryl Trinitrate (GTN) in the Treatment of uncomplicated Chronic Anal Fissure (CAF)

Authors

  • Shima Akter Khatun Assistant Professor, Department of Pharmacology, Dhaka National Medical College
  • Md Rashidul Islam 2Associate Professor, Department of Colo-rectal Surgery, Shahid Suhrawardy Medical College,
  • Halima Khatun Associate Professor, Department of Pharmacology, Enam Medical College
  • Farhana Islam Senior Lecturer, Department of Pharmacology, Dhaka National Medical College
  • Shusmita Saha Professor (cc.), Department of Pharmacology, Dhaka National Medical College

DOI:

https://doi.org/10.3329/jdnmch.v27i2.80134

Keywords:

Chronic anal fissure, Glyceryl Trinitrate, Visual analogue scale

Abstract

Objective: To determine the therapeutic effectiveness of Glyceryl trinitrate (GTN) in the treatment of uncomplicated chronic anal fissure

Materials and Methods: Prospective observational Study conducted in a private hospital in Dhaka City from Jan 2019 to Dec 2019. Forty eight patients of chronic anal fissure were included in this study. There were 28 (58.33%) females and 20 (41.66%) males with mean age of 37.Pain was documented using visual analogue scale. At presentation all patients (100%) perceived pain as severe pain on Visual Analogue Scale. Patients were started treatment with local application of Glyceryl Trinitrate (GTN) gel, twice daily and reassessed after 04 weeks and 08 weeks of treatment respectively. Pain and healing of fissure were documented.

Results: Significant pain relief was observed in 46% patient & fissure healing was observed in 31.25% patient. The commonest side effect of treatment was headache (26%).

Conclusion: Glyceryl trinitrate is very effective in the treatment of chronic anal fissure and is the drug of choice in conservative treatment of anal fissures and in patients with contraindications for surgery

J. Dhaka National Med. Coll. Hos. 2021; 27 (02): 26-29

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Published

2021-09-30

How to Cite

Khatun, S. A., Islam, M. R., Khatun, H., Islam, F., & Saha, S. (2021). Therapeutic effectiveness of Glyceryl Trinitrate (GTN) in the Treatment of uncomplicated Chronic Anal Fissure (CAF). Journal of Dhaka National Medical College & Hospital, 27(2), 26–29. https://doi.org/10.3329/jdnmch.v27i2.80134

Issue

Vol. 27 No. 2 (2021)

Section

Original Articles