Serum Calcium and Phosphate in Children with Autism Spectrum Disorder

  • Sharmin Afroz Lecturer, Department of Physiology, Mugda Medical College, Dhaka, Bangladesh
  • Umme Raihan Siddiqi Department of Physiology, Shaheed Suhrawardy Medical College, Dhaka, Bangladesh
  • Nusrat Mahruba Department of Physiology, Ibrahim Medical College, Dhaka, Bangladesh
  • Shorifa Shahjadi Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
  • Shelina Begum Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Keywords: ASD, Calcium, Phosphate

Abstract

Background:Autism spectrum disorder (ASD) is a complex disorder of neuronal development which may cause lifelong disability. The etiology of ASD involves gene-environmental interaction. Calcium signal is crucial for neuronal communication and neuro-plasticity and phosphate is related to neural energy metabolism. Therefore, deficiency of these minerals may act as an environmental risk factor for the development of ASD.

Objective: To assess serum calcium and phosphate in children with ASD.

Methods: This cross-sectional comparative study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University(BSMMU) Dhaka from March 2018 to February 2019. For this, 50 ASD children of both sex (age 3 to10 years) diagnosed by pediatric neurologist were included as ‘Study’ participants through ‘Parents Forum of differently abled children, Mohakhali, Dhaka’ and for comparison, age, BMI and sex matched 50 apparently healthy children were enrolled, as ‘Control’. Serum calcium and phosphate level of all children were estimated by colorimetric method. All data were expressed as mean±SD, range and percentage. For statistical analysis, Chi- Square test, Shapiro Wilk test and independent sample ‘t’ test was done, as applicable.

Results:The mean serum calcium was significantly (p<0.01) lower in ASD children compared to control, though the mean values were within normal reference range in both groups. However, hypophosphatemia was found in 4% of ASD children.

Conclusion:From this study, it may be concluded that ASD children was associated with lower serum calcium level and hypophosphatemia.Therefore, adequate dietary intake of calcium and phosphate is recommended for children with ASD.

J Bangladesh Soc Physiol. 2020, December; 15(2): 72-77

Downloads

Download data is not yet available.
Abstract
208
PDF
189
Published
2020-12-23
How to Cite
Afroz, S., Siddiqi, U., Mahruba, N., Shahjadi, S., & Begum, S. (2020). Serum Calcium and Phosphate in Children with Autism Spectrum Disorder. Journal of Bangladesh Society of Physiologist, 15(2), 72-77. https://doi.org/10.3329/jbsp.v15i2.50921
Section
Articles