Journal of Bangladesh Society of Physiologist https://www.banglajol.info/index.php/JBSP <p>Established in 2006 by the Bangladesh Society of Physiologist Full text articles available.</p><p>Journal of Bangladesh Society of Physiologist is included on <a title="DOAJ" href="https://doaj.org/toc/2219-7508" target="_blank">DOAJ</a>.</p> Bangladesh Society of Physiologist en-US Journal of Bangladesh Society of Physiologist 1995-1213 <p>JBSP retains the copyright of the contents of this journal but grant the readers the right to use the contents with terms and conditions under a creative common attribution licenses 4 of Attribution, Share Alike and Non commercial type(CC BY-NC-SA) that allows copy, distribute, display, and perform the work and make derivative works based on it only for noncommercial purposes.</p><p><a href="http://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license"><img style="border-width: 0;" src="https://i.creativecommons.org/l/by-nc-sa/4.0/88x31.png" alt="Creative Commons Licence" /></a><br />Journal of Bangladesh Society of Physiologist is licensed under a <a href="http://creativecommons.org/licenses/by-nc-sa/4.0/" rel="license">Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License</a>. </p> Role of blood neutrophil to lymphocyte ratio and serum total IgE in diagnosis of asthma-COPD overlap among patients with COPD https://www.banglajol.info/index.php/JBSP/article/view/50918 <p><strong>Background: </strong>Some clinical and spirometric features are common to both COPD and asthma-COPD overlap (ACO), causing difficulties in distinguishing these airway diseases from each other. Since, both of them are characterized by airway inflammation, any inflammatory biomarker as blood neutrophil to lymphocyte ratio and serum total IgE can be used for this purpose.</p> <p><strong>Objectives: </strong>To assess the role of blood neutrophil to lymphocyte ratio and serum total IgE in the diagnosis of ACO among patients with COPD.</p> <p><strong>Methods: </strong>This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka from March 2019 to February 2020. For this, 63 male stable patients (age 40 to 80 years) of COPD were enrolled and 51 of them were finally selected according to exclusion criteria. Then these 51 COPD patients were divided into ACO and COPD-alone groups, based on criteria from the joint document by the Global Initiative for Asthma (GINA) and the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Blood neutrophil to lymphocyte ratio (NLR) and serum total IgE of all patients were measured by standard lab procedure. For statistical analysis, Chi-Square test, Fisher exact test, Shapiro Wilk test, Mann-Whitney U test and receiver operating characteristic (ROC) curve analysis were done, as applicable.</p> <p><strong>Results: </strong>Among the 51 COPD patients, 26 patients were diagnosed with ACO and 25 patients were with COPD-alone. Here, NLR was significantly lower (median 2.09 vs 3.43, respectively; p&lt;0.001) in ACO patients than that of COPD-alone. In addition, NLR showed ‘very good’ (area under ROC curve 0.815) diagnostic accuracy.</p> <p><strong>Conclusion: </strong>The present study reveals that, blood neutrophil to lymphocyte ratio, but not serum total IgE can play substantial role in diagnosis of ACO among the patients with COPD</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 54-60</p> Md Monimul Islam Md Ali Hossain Kazi Saifuddin Bennoor Taskina Ali Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 54 60 10.3329/jbsp.v15i2.50918 Morphometric study of the size of the postmortem human kidney https://www.banglajol.info/index.php/JBSP/article/view/50919 <p><strong>Background: </strong>Changes in the size of the kidney are evident in humans, as age progresses.</p> <p><strong>Objective: </strong>To see the age-related changes in the morphological dimensions of the kidney in a sample of the Bangladeshi population.</p> <p><strong>Methods: </strong>This crosssectional study was done in the Department of Anatomy, Dhaka Medical College, Dhaka, from July 2008 to June 2009, based on a collection of 140 postmortem human kidneys collected from 70 unclaimed dead bodies from the morgue of the same institution. All the samples of kidney were divided into three age groups, including A (10-19 years), B (20-39 years) and C (40-59 years). The length, breadth and thickness of all the kidneys were measured by using a slide calipers and recorded. Data were expressed as mean±SD. For statistical analysis, independent sample t test and one way ANOVA was used.</p> <p><strong>Results: </strong>The length of the right and left kidneys found were 8.72±0.25 cm and 9.28±0.12 cm; 9.73±0.35 cm and 10.31±0.41 cm; 9.68±0.21 cm and 10.24±0.06 cm in group A, B and C respectively. The breadth of the right and left kidneys found were 4.32±0.09 cm and 4.22±0.11 cm; 4.74±0.29 cm and 4.55±0.28 cm; 4.61±0.21 cm and 4.44±0.21 cm in group A, B and C respectively. The thickness of the right and left kidneys found were 2.84±0.10 cm and 2.64±0.05 cm; 3.31±0.16 cm and 3.11±0.10 cm; 3.17±0.07 cm and 3.11±0.10 cm in group A, B and C respectively. The mean length of the left kidneys was found significantly greater than that of the right , whereas the mean breadth and the thickness of the right kidneys were found greater than that of the left kidney in all age groups. Moreover, age related changes were significant in all dimensions (length, breadth and thickness) of the kidney when compared between group A &amp; B and A &amp; C.</p> <p><strong>Conclusion: </strong>This study results concluded that the length of the left kidney was greater than that of the right, but the breadth and the thickness of the right kidney were greater than that of the left one in all age groups. In addition, age related changes in all dimensions (i.e. length, breadth and thickness) of the kidneys were evident in middle age versus young adult and older adult versus young adult.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 61-67</p> Fatema Johora Abu Sadat Mohammad Nurunnabi Dilruba Siddiqua Hasna Hena Shamim Ara Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 61 67 10.3329/jbsp.v15i2.50919 Effects of exposure to textile dye on serum Alkaline Phosphatase and Gamma Glutamyl Transferase levels in textile industry workers https://www.banglajol.info/index.php/JBSP/article/view/50920 <p><strong>Background</strong>: The textile dyeing industry uses large number of chemicals, acids and dyes. The workers are exposed to these chemicals during their daily work activities. Chronic exposure to these chemicals may have adverse effect on the liver functions, as liver plays an important role in detoxification of these chemicals</p> <p><strong>Objective: </strong>To assess serum Alkaline Phosphatase (ALP) and Gamma glutamyl transferase (GGT) levels of the industrials workers exposed to textile dyes.</p> <p><strong>Methods: </strong>This cross sectional study was carried out in the Department of Physiology,Dhaka Medical College, Dhaka from July 2016 to June 2017 on 25 apparently healthy male workers aged 20-40 years working in a textile dye factory for 2 years or more. Similar age, sex, BMI &amp; socioeconomically matched 25 apparently healthy non exposed workers were enrolled as control. Serum ALP and GGT levels were estimated by autoanalyzer. For statistical analysis unpaired Student’s t-test were performed</p> <p><strong>Results: </strong>Serum ALP and GGT levels were significantly higher in textile dye exposed workers than those of control group (p &lt;0.05).</p> <p><strong>Conclusions:</strong>This study reveals that exposure to textile dyes have deteriorating effect on liver function.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 68-71</p> Sayeda Tasnim Kamal Qazi Shamima Akhter Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 68 71 10.3329/jbsp.v15i2.50920 Serum Calcium and Phosphate in Children with Autism Spectrum Disorder https://www.banglajol.info/index.php/JBSP/article/view/50921 <p><strong>Background:</strong>Autism spectrum disorder (ASD) is a complex disorder of neuronal development which may cause lifelong disability. The etiology of ASD involves gene-environmental interaction. Calcium signal is crucial for neuronal communication and neuro-plasticity and phosphate is related to neural energy metabolism. Therefore, deficiency of these minerals may act as an environmental risk factor for the development of ASD.</p> <p><strong>Objective: </strong>To assess serum calcium and phosphate in children with ASD.</p> <p><strong>Methods: </strong>This cross-sectional comparative study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University(BSMMU) Dhaka from March 2018 to February 2019. For this, 50 ASD children of both sex (age 3 to10 years) diagnosed by pediatric neurologist were included as ‘Study’ participants through ‘Parents Forum of differently abled children, Mohakhali, Dhaka’ and for comparison, age, BMI and sex matched 50 apparently healthy children were enrolled, as ‘Control’. Serum calcium and phosphate level of all children were estimated by colorimetric method. All data were expressed as mean±SD, range and percentage. For statistical analysis, Chi- Square test, Shapiro Wilk test and independent sample ‘t’ test was done, as applicable.</p> <p><strong>Results:</strong>The mean serum calcium was significantly (p&lt;0.01) lower in ASD children compared to control, though the mean values were within normal reference range in both groups. However, hypophosphatemia was found in 4% of ASD children.</p> <p><strong>Conclusion:</strong>From this study, it may be concluded that ASD children was associated with lower serum calcium level and hypophosphatemia.Therefore, adequate dietary intake of calcium and phosphate is recommended for children with ASD.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 72-77</p> Sharmin Afroz Umme Raihan Siddiqi Nusrat Mahruba Shorifa Shahjadi Shelina Begum Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 72 77 10.3329/jbsp.v15i2.50921 Cardiovascular responses to tilting in Type 2 Diabetic patients https://www.banglajol.info/index.php/JBSP/article/view/50922 <p><strong>Background: </strong>Diabetes mellitus (DM) is a disorder with a debilitating effects on cardiac autonomic control. Multiple major cardiovascular risk factors associated with DM led diabetic patients at high risk of Cardiovascular Disease.</p> <p><strong>Objective: </strong>To assess cardiovascular responses to tilting in Type 2 Diabetic patients (T2DM) with normal and abnormal autonomic function test.</p> <p><strong>Methods: </strong>This experimental study was conducted on 60 patients of T2DM. Among them, 30 patients were with normal cardiovascular reflex test (group DN) and 30 patients were with abnormal test (group DA). Thirty(30) apparently healthy subjects with similar age and sex without any physical illness were enrolled as control. Tilt table test of all subjects was done by tilting at 60° for 10 min by using a motorized tilt table. Cardiovascular response to tilt test was assessed by calculating D Heart rate (Acceleration index and Brake index); DSBP (SBP <sub>30s-0</sub> and SBP<sub>1 min -0</sub>), DDBP (DBP <sub>30s-0</sub> and DBP<sub>1 min -0</sub>) after tilting. For statistical analysis, one-way ANOVA followed by Bonferroni post hoc was used.</p> <p><strong>Results: </strong>In this study, the Acceleration index was significantly higher in patient group DN compared to control and DA(p&lt;0.001). But the Brake index was significantly (p&lt;0.01, p&lt;0.05) lower in both group of patients compared to control. In addition, SBP <sub>30sec-0</sub> and SBP<sub>1 min-0 </sub>were significantly higher in DA than those of control and DN.DBP <sub>30sec-0</sub> and DBP<sub>1min-0 </sub>were significantly (p&lt;0.001) lower in DA patients compared to DN and control.</p> <p><strong>Conclusion: </strong>This study concluded that cardiovascular response to tilting was weak in T2DM patients and it was greatly affected in T2DM patients with abnormal autonomic function test.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 78-84</p> Iffat Rejwana Sadia Afrin Rimi Shamima Sultana Sultana Ferdousi Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 78 84 10.3329/jbsp.v15i2.50922 Effects of green tea on glycemic status in female metabolic syndrome patients https://www.banglajol.info/index.php/JBSP/article/view/50923 <p><strong>Background: </strong>According to International Diabetic Federation, around 20-25% of world adult population have the clinical features of metabolic syndrome (MetS). Different organizations recommend to modify lifestyle and dietary habit as primary intervention. Green tea has several pharmacological effects on metabolic diseases including MetS.</p> <p><strong>Objective: </strong>To evaluate the effects of green tea consumption on two glycemic variables in women with MetS.</p> <p><strong>Method: </strong>This interventional study was conducted in the Department of Physiology, Dhaka Medical College from January 2016 to December 2016. After fulfilling the ethical aspect, a total number of 42 female patients with MetS aged 40 to 50 years were selected from the outpatient department of Endocrinology, Dhaka Medical College Hospital. Participants were randomly assigned in study group (n=22) and control group (n=20). Study group consumed green tea for 12 weeks and the control group did not consume green tea. In both groups fasting serum glucose (FSG) and glycosylated hemoglobin (HbA1c) were measured by glucose oxidase (GOD/ PAP) method and modified high performance liquid chromatography (HPLC) method respectively 2 times (before and after 12 weeks). Data were analyzed by paired Student’s ‘t’ test and unpaired Student’s ‘t’ test.</p> <p><strong>Results: </strong>After 12 weeks of intervention, FSG &amp; HbA1c significantly (p&lt;0.001) decreased in the study group than those of their baseline value and these values were also significantly (p&lt;0.05) lower in comparison to those of control group.</p> <p><strong>Conclusions: </strong>Regular consumption of green tea may improve glycemic status in patients with metabolic syndrome.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 85-90</p> Sabira Tabassum Qazi Shamima Akhter Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 85 90 10.3329/jbsp.v15i2.50923 Correlation of placental morphometry with the birth weight of newborn in Kerala population https://www.banglajol.info/index.php/JBSP/article/view/50924 <p><strong>Background:</strong>Morphology and morphometric measurements of the placenta will provide an insight into the aetiology of newborn and maternal complications.</p> <p><strong>Objective:</strong>This study aimed to observe the gross morphometric assessment of placenta and to correlate the placental indices with birth weight of the baby in hypertensive and normal pregnancies.</p> <p><strong>Methods:</strong>The present study was a comparative descriptive study with analytical components. A total of 86 pregnant women comprising 40 normotensive subjects and 46 hypertensive women within the age group of 18-40 years, parity between 1-4, gestational age between 37 weeks-40 weeks, who attended antenatal clinic of the hospital and delivered by either vaginal route or caesarean section were included in this study. After collecting their placenta, the weight, diameter, surface area, thickness, shape of the placentae was recorded. Weight and sex of baby was also recorded. For statistical analysis, Pearson correlation coefficient test was employed.</p> <p><strong>Results: </strong>Positive correlation was observed between the placental surface area (p&lt;0.05; p&lt;0.001), diameter (p&lt;0.05; p&lt;0.001) weight (p&lt;0.001; p&lt;0.05) and the corresponding birth weight of the baby among both the normotensive and the hypertensive mothers. All these relationships were statistically significant.</p> <p><strong>Conclusion: </strong>From this study, it can be concluded that placental morphometry has a direct relationship with the birth weight of the baby irrespective of the blood pressure of the mother during pregnancy.The study results may help in understanding of the maternal-placental programming of chronic diseases</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 91-97</p> Akshara Venmalassery Rajeev SaiSailesh Kumar Goothy Chitra Srinivasan Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 91 97 10.3329/jbsp.v15i2.50924 Impact of Vitamin D supplementation on Heart Rate Variability in Vitamin D deficient Asthma COPD Overlap Syndrome patients: A Randomized Controlled Trial https://www.banglajol.info/index.php/JBSP/article/view/50925 <p><strong>Background:</strong>Vitamin D<sub>3</sub> deficiency is common in Asthma COPD overlap syndrome (ACO) and administration of vitamin D3 increased heart rate variability in healthy subjects.</p> <p><strong>Objective: </strong>This randomized clinical trial aimed to investigate the therapeutic effect of vitamin D<sub>3</sub>administration on time domain measures of heart rate variability in 51 male vitamin D3(&lt;30- 10ng/ml) deficient ACO patients.</p> <p><strong>Methods: </strong>Patients were given either vitaminD<sub>3</sub> capsule or placebo per week orally for 3 months and serum vitamin D3 level and time domain parameters of heart rate variability were assessed before and after the intervention. For statistical analysis, independent and paired sample t test was used.</p> <p><strong>Results: </strong>Before intervention, vitamin D<sub>3</sub> level and time domain parameters of heart rate variability were similar in all patients but these outcome measures significantly increased in vitamin D<sub>3</sub> treated but not in placebo treated patients after 3 months.</p> <p><strong>Conclusion:</strong>In conclusion, vitaminD<sub>3</sub>therapy is effective to improve heart rate variability in vitamin D<sub>3</sub> deficient Asthma COPD overlap syndrome.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 98-107</p> Salsa Bill Nahar Sultana Ferdousi Shamima Sultana Kazi Saifuddin Bennoor Mustafijur Rahman Mohammad Abdus Shakur Khan Samia Hassan Maksuda Binte Mahmood Sharkia Khanam Rosy Nazneen Sultana Sheikh Manna Yasmin Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 98 107 10.3329/jbsp.v15i2.50925 Erratum: Role of blood cells in diagnosis of asthma-COPD overlap among patients with COPD https://www.banglajol.info/index.php/JBSP/article/view/50926 <p><strong>Background: </strong>As asthma-COPD overlap (ACO) and COPD share some common clinical features, this makes difficult to distinguish them from each other. Since, both of them are characterized by airway inflammation, any inflammatory biomarker such as total count (TC) of white blood cells (WBC), neutrophil, eosinophil and platelet can be used for that purpose.</p> <p><strong>Objective: </strong>To assess the role of TC of WBC, neutrophil, eosinophil and platelet in diagnosis of ACO among patients with COPD.</p> <p><strong>Methods: </strong>This cross sectional study was conducted in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University, Dhaka from 2019 March to Feb 2020. In this study, 63 male stable patients (age range: 40 to 80 years) of COPD were enrolled. Among them, 51 patients were finally selected according to exclusion criteria and divided into two groups, ACO (n=26) and COPD alone (n=25). TC of WBC, neutrophil, eosinophil and platelet of all patients were measured by standard lab procedure. For statistical analysis, Chi-Square and Fisher exact test, Shapiro-Wilk test, Mann-Whitney U test were done as applicable. More over, receiver operating characteristic (ROC) curve analysis was performed.</p> <p><strong>Results: </strong>In the present study, TC of WBC and neutrophil count were significantly (p&lt;0.01) lower, whereas, blood eosinophil count was significantly (p&lt;0.05) higher in ACO patients than those of COPD-alone. In addition, highest area under the receiver operating characteristic curve was found in case of blood neutrophil count, followed by TC of WBC and eosinophil count. Moreover, at optimal cut off value, the sensitivity, specificity, positive predictive value, negative predictive value of blood count of total WBC were calculated as, 72.00, 61.50, 64.28, 69.56, respectively. However, the aforementioned indices were observed for blood neutrophil count, as 72.00, 76.90, 75.00, 74.07 and for blood eosinophil count, as 38.50%, 92.00%, 83.33%, 58.97%, respectively.</p> <p><strong>Conclusion:</strong>The present study reveals that blood count of total WBC, neutrophil and eosinophil, but not the platelet, play substantial role in diagnosis of ACO among the patients with COPD.</p> <p>J Bangladesh Soc Physiol. 2020, December; 15(2): 108-114</p> Md Monimul Islam Md Ali Hossain Kazi Saifuddin Bennoor Taskina Ali Copyright (c) 2020 Journal of Bangladesh Society of Physiologist 2020-12-23 2020-12-23 15 2 108 114 10.3329/jbsp.v15i2.50926