Prolong Omeprazole Therapy Impacts on Biochemical Parameters in Peptic Ulcer Disease Patients

Authors

  • Mohammad Nesar Uddin Ahmed Instructor of Physiology, Armed Forces Medical College, Dhaka
  • Quazi Md Rashid-Un-Nabi Director General Medical Services, DGMS, Ministry of Defence, Dhaka Cantonment
  • Ahmed Lutful Moben Assistant Professor of Hepatology, Kurmitola General Hospital, Dhaka
  • Suhana Suhana Diploma Trainee (Ophthalmology), Armed Forces Medical Institute, Dhaka
  • Md Nurul Islam Khan Medical Officer (ENT), Sarkari Karmachari Hospital, Dhaka
  • Mohammad Nurunnabi Assistant Professor of Community Medicine and Public Health, Sylhet Women’s Medical College, Sylhet.

DOI:

https://doi.org/10.3329/jafmc.v21i1.83939

Keywords:

PPIs, Prolong use, PUD, lipid profile, liver enzymes, kidney function, serum ferritin, calcium levels

Abstract

Background: Prolonged use of proton pump inhibitors (PPIs) is associated with a range of potential adverse effects. Omeprazole, one of the most widely prescribed PPIs globally, is commonly used in clinical practice.

Objective: To assess the impact of prolonged omeprazole use on specific biochemical markers in individuals receiving treatment for a year or more.

Methods: This case-control study was conducted in the Department of Physiology of Armed Forces Medical College, Dhaka Cantonment using data obtained from at the Department of Medicine (Gastroenterology), Kurmitola General Hospital, Dhaka from October 2023 to March 2024, enrolling 122 participants; 62 patients diagnosed with uncomplicated peptic ulcer disease (PUD) (32 females, 30 males) and 60 age- matched healthy controls (30 females, 30 males)-selected from individuals aged 30 to 65 years presenting with epigastric symptoms and confirmed as diagnosed case of PUD through upper gastrointestinal endoscopy.

Results: While high-density lipoprotein levels were unaffected (p>0.05), prolonged use of omeprazole was related to significant increases in triglycerides, cholesterol and low-density lipoprotein levels (p<0.05). There was no discernible change in the levels of alanine aminotransferase (p>0.05), however there were elevated levels of alkaline phosphatase (p=0.001) and aspartate aminotransferase (p=0.001). Further, the group treated with omeprazole had significantly higher creatinine levels (p=0.001). Serum ferritin and calcium levels were also significantly lower (p<0.05) in peptic ulcer patients than in healthy controls.

Conclusion: The study's findings demonstrate that Omeprazole use for a prolonged period of time is related to substantial changes in lipid profiles, liver enzymes, kidney function indicators and essential minerals, implying potential impacts on patients' metabolic and biochemical state of health.

JAFMC Bangladesh, Vol 21, No 1 (June) 2025:07-11

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Published

2026-01-14

How to Cite

Ahmed, M. N. U., Rashid-Un-Nabi, Q. M., Moben, A. L., Suhana, S., Khan, M. N. I., & Nurunnabi, M. (2026). Prolong Omeprazole Therapy Impacts on Biochemical Parameters in Peptic Ulcer Disease Patients. Journal of Armed Forces Medical College, Bangladesh, 21(1), 07–11. https://doi.org/10.3329/jafmc.v21i1.83939

Issue

Vol. 21 No. 1 (2025)

Section

Original Papers

License

Submission of a manuscript for publication implies the transfer of the copyright from the author to the publisher upon acceptance. Accepted manuscripts become the permanent property of the Journal of Armed Forces Medical College and may not be reproduced by any means in whole or in part without the written consent of the publisher.