Antioxidatant Effect of Atorvastatin and Rosuvastatin in Hyperlipidemic Patients: A Randomized Controlled Trial

  • Samia Haque Tonu Assistant Professor of Pharmacology, International Medical College, Gazipur
  • Jasmine Fauzia Dewan Professor and Chairman, Department of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka
  • Nargis Akhter Professor of Pharmacology, Bangabandhu Sheikh Mujib Medical University, Dhaka
  • Md Enamul Haque Graded Specialist in Surgery Department of Surgery, Combined Military Hospital, Dhaka Cantonment
  • Md Abdul Wahab Associate Professor of Biochemistry, AFMC, Dhaka
Keywords: Statin, Oxidative stress; Atherosclerosis

Abstract

Introduction: Hyperlipidemia is a major risk for the development of atherosclerosis leading to cardiovascular complications. Atorvastatin and rosuvastatin are two widely used important members of the HMG-CoA reductase inhibitor (statins). The beneficial effects of statins on clinical events also involve lipid-independent mechanisms which include improvement of oxidative stress status.

Objective: To compare the antioxidative effect of atorvastatin and rosuvastatin in patients with hyperlipidemia.

Materials and Methods: A prospective randomized single-center analytic study was carried out in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March 2016 to August 2017 on 52 hyperlipidemic patients. After randomization patients were assigned to atorvastatin 10 mg or rosuvastatin 5 mg daily for 8 weeks. Blood was collected at baseline and after the intervention to measure plasma malondialdehyde (MDA), erythrocyte reduced glutathione (GSH) (as biomarkers of oxidative stress) and serum lipid profile.

Results: The baseline characteristics of patients treated with atorvastatin and rosuvastatin were almost identical. The level of plasma MDA in atorvastatin (1.35 ± 0.94 to 0.97± 0.64) and rosuvastatin (1.56±0.69 to 0.98±0.38) group was significantly reduced after intervention (28.15%, p<0.05 and 37.18%, p<0.001 respectively) but no statistically significant difference (p>0.05) was observed between the two statin-treated groups. Erythrocyte GSH level was increased after intervention in both atorvastatin (2.43±2.90 to 4.14 ± 4.87) group (70.37%, p<0.01) and rosuvastatin (2.76±3.80 to 8.36±12.93)  group (202.90%, p<0.01), which was statistically significant. No significant difference was observed between the two groups (p>0.05). Both atorvastatin and rosuvastatin significantly improved serum lipid profile.

Conclusion: Both atorvastatin and rosuvastatin significantly improved oxidative stress status in hyperlipidemic patients but no significant change was observed between the two statin-treated groups.

Journal of Armed Forces Medical College Bangladesh Vol.14(1) 2018: 54-58

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Abstract
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Published
2019-08-22
How to Cite
Tonu, S. H., Dewan, J. F., Akhter, N., Haque, M. E., & Wahab, M. A. (2019). Antioxidatant Effect of Atorvastatin and Rosuvastatin in Hyperlipidemic Patients: A Randomized Controlled Trial. Journal of Armed Forces Medical College, Bangladesh, 14(1), 54-58. https://doi.org/10.3329/jafmc.v14i1.42723
Section
Original Papers