Nanosuspension: A Novel Drug Delivery System

Authors

  • Bhatt Ganesh Shri Guru Ram Rai Institute of Technology & Sciences Dehradun, Uttarakhand
  • Raturi Ankita Shri Guru Ram Rai Institute of Technology & Sciences Dehradun, Uttarakhand
  • Kothiyal Preeti Shri Guru Ram Rai Institute of Technology & Sciences Dehradun, Uttarakhand

DOI:

https://doi.org/10.3329/ijpls.v2i4.17117

Keywords:

Nanosuspensions, Solubility, Bioavailability, methods of preparation, Homogenization, Drug Delivery

Abstract

Low bioavailability is the major problem associated with poorly soluble drugs. The problem is more complex for drugs which are poorly soluble in both aqueous and nonaqueous media, as solubility is an essential factor for drug absorption, independent of the route of administration. Nanosuspensions have emerged as an attractive and promising approach to improve stability and bioavailability of poorly soluble drugs. These are very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1?m, without any matrix material, stabilized by surfactants and polymers. Techniques such as wet milling, high-pressure homogenization, emulsification-solvent evaporation and supercritical fluid have been used in the preparation of nanosuspension. Nanosuspension can be delivered by oral, parenteral, pulmonary and ocular routes.

DOI: http://dx.doi.org/10.3329/ijpls.v2i4.17117

International Journal of Pharmaceutical and Life Sciences Volume 2, Issue 4: October 2013; 179-196

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Published

2013-11-24

How to Cite

Ganesh, B., Ankita, R., & Preeti, K. (2013). Nanosuspension: A Novel Drug Delivery System. International Journal of Pharmaceutical and Life Sciences, 2(4), 179–196. https://doi.org/10.3329/ijpls.v2i4.17117

Issue

Section

Review Articles