Synergistic Effects of Disintegrants on Release of poorly Water soluble drug

Authors

  • Md Mofizur Rahman Department of Pharmacy, Bangladesh University, Dhaka
  • Abul Basar Khalpha Department of Pharmacy, Bangladesh University, Dhaka
  • Amit Kumar Chaurasiya Department of Pharmacy, Bangladesh University, Dhaka
  • Mithilesh Kumar Jha Department of Pharmacy, Bangladesh University, Dhaka
  • Md Qamrul Ahsan Department of Pharmacy, Southern University
  • Zakaria Faruki Department of Pharmacy, Bangladesh University, Dhaka
  • Md Jannatul Ferdaus Department of Pharmacy, Primeasia University, Dhaka

DOI:

https://doi.org/10.3329/ijpls.v1i3.12979

Keywords:

Acetaminophen, disintegrants, wet granulation, intragranularly, extragranularly

Abstract

We have done research work in lab to find out proper formulation of immediate release tablet by using of various types of disintegrants (crospovidone, sodium starch glycolate and sodium carboxymethylcellulose), in order to examine the effect of mode of absorption of disintegrants on release mechanism from tablets. Acetaminophen, a poor soluble drug was used as a model drug to estimate its release pattern from different formulations. The USP paddle method was selected to perform the dissolution profiles carried out by USP apparatus 2 (paddle) at 50 rpm in 900 ml phosphate buffer pH 5.8. Successive dissolution time, time required for 25%, 50% and 80% of the drug release (T25%, T50%, T80%) was used to evaluate the dissolution results. A One way analysis of variance (ANOVA) was used to recognize the result. Statistically significant differences were found among the drug release profile from all the formulations except mode of addition of crosspovidone. At a fixed amount of disintegrants, extragranular mode of addition seemed to be the best mode of incorporation. The best release was achieved with the sodium carboxymethylcellulose and sodium starch glycolate containing formulations. The T50 and T80 values were analytical of the fact that the drug release was faster from tablet formulations containing carboxymethylcellulose and sodium starch glycolate. The drug release was very much negligible difference by the mode of crospovidone addition. Two formulations found very small T50 and T80 values indicating very much faster release. From the all formulations corresponded extragranular mode of addition could be the best mode of incorporation. The drug release was unaffected by the mode of crospovidone addition. The mode of incorporation of disintegrants suggested enchancing the release of poor soluble drugs.

DOI: http://dx.doi.org/10.3329/ijpls.v1i3.12979

International Journal of Pharmaceutical and Life Sciences Vol.1(3) 2012

Downloads

Download data is not yet available.
Abstract
1480
PDF
730

Downloads

Published

2012-12-15

How to Cite

Rahman, M. M., Khalpha, A. B., Chaurasiya, A. K., Jha, M. K., Ahsan, M. Q., Faruki, Z., & Ferdaus, M. J. (2012). Synergistic Effects of Disintegrants on Release of poorly Water soluble drug. International Journal of Pharmaceutical and Life Sciences, 1(3). https://doi.org/10.3329/ijpls.v1i3.12979

Issue

Section

Research Articles