Blood Lactate Level as Predictor of Early Outcome after Off-Pump Coronary Artery Bypass Grafting

Authors

  • Nasrin Aktar Department of Cardiac Surgery, Khulna City Medical college, Khulna, Bangladesh
  • AM Asif Rahim Department of Cardiac Surgery, Chattogram Medical College Hospital, Chattogram, Bangladesh
  • AYM Shahidullah Department of Cardiac Surgery, Khulna City Medical college, Khulna, Bangladesh
  • AHM Iftekher Hossain Department of Cardiac Surgery, Chattogram Medical College Hospital, Chattogram, Bangladesh
  • Farooque Ahmed Department of Cardiac Surgery,National Heart Foundation Hospital and Research Institute, Dhaka, Bangladsh

DOI:

https://doi.org/10.3329/cardio.v12i2.47989

Keywords:

Blood Lactate Level, Coronary Artery Bypass grafting, Ischaemic heart disease.

Abstract

Background: Identification of predictors of morbidity and mortality is an important issue for the management of cardiac surgical patients. Elevated lactate concentrations in the immediate postoperative period reflect unmet metabolic demand and may be associated with outcome.

Methods: A prospective observational study was carried out in the department of cardiac surgery, at National Heart Foundation Hospital& Research Institute(NHFH&RI), Dhaka. commencing from July 2016 to March 2018. In all Adult patients irrespective of sex undergoing elective off-pump coronary artery bypass grafting (OPCABG). Purposive sampling was applied with patient with blood lactate level < 3 mmol/L 6hours after shifting from OT to ICU in Group-A and blood lactate level ≥3mmol/l, 6hours after shifting to the ICU in Group-B.Postoperative early adverse outcomes were analyzed in both the patient groups.

Results: Blood lactate level 6 hours after ICU transfer is an independent predictor for prolonged mechanical ventilation time, (OR 2.540, 95% CI 1.781-3.621, p= <0.001).prolonged ICU stay, .(OR 1.767, 95% CI 1.348-2.315, p=< 0.001) pulmonary complication (OR 1.503, 95% CI 1.104-2.046, p= 0.010).and renal dysfunction(OR 1.460, 95% CI 1.156-1.843, p= 0.001). following off-pump coronary artery bypass grafting. Other risk factors for adverse outcome including, low LVEF, diabetes mellitus, blood transfusion and inotropic support were also found to be predictors of major complications in our study.

Conclusion: The findings of this study permits to conclude that blood lactate level 6hours after ICU transfer is associated with an increased risk of postoperative early adverse outcome after off-pump coronary artery bypass grafting. It is found that lactate is an independent predictor of major postoperative complications. So, achieving normal blood lactate level following OPCABG is essential for minimizing postoperative adverse outcome.

Cardiovasc. j. 2020; 12(2): 120-125

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Published

2020-07-03

How to Cite

Aktar, N., Rahim, A. A., Shahidullah, A., Hossain, A. I., & Ahmed, F. (2020). Blood Lactate Level as Predictor of Early Outcome after Off-Pump Coronary Artery Bypass Grafting. Cardiovascular Journal, 12(2), 120–125. https://doi.org/10.3329/cardio.v12i2.47989

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Section

Original Articles