Study of Cardiac Troponin I level in Acute Coronary Syndrome and its correlation with Left Ventricular Systolic Function

  • Mohammad Jakir Hossain Enam Medical College, Dhaka
  • Khondoker Asaduzzaman Sir Salimullah Medical College, Dhaka
  • Solaiman Hossain Enam Medical College, Dhaka
  • Muhammad Badrul Alam Sir Salimullah Medical College, Dhaka
  • Nur Hossain Sir Salimullah Medical College, Dhaka
Keywords: Acute coronary syndrome, Troponin I, LV function

Abstract

Background: In the diagnosis of acute coronary syndrome, cardiac troponin I is highly reliable and widely available biomarker. Serum level of cardiac troponin I is related to amount of myocardial damage and also closely relates to infarct size. Our aim of the study is to find out the relationship between cardiac troponin I and left ventricular systolic function after acute coronary syndrome.

Methods: Total of 132 acute coronary syndrome patients were included in this study after admission in coronary care unit of Sir Salimullah Medical College, Mitford Hospital. Troponin I level was measured at admission and left ventricular ejection fraction (LVEF) was measured by echocardiography between 12-48 hours of onset of chest pain.

Results: There was negative correlation between Troponin I at 12 to 48 hours of chest pain with LVEF in these study patients. With a cutoff value of troponin I e”6.8 ng/ml in STEMI patients there is a significant negative relation between 12 to 48 hrs troponin I and LVEF (p<0.001). Sensitivity of troponin I e” 6.8 ng/ml between 12 to 48 hours of chest pain in predicting LVEF <50% in STEMI was 93.75% and specificity was 77.78%. In NSTEMI sensitivity of troponin I e” 4.5 ng/ml between 12 to 48 hours of chest pain in predicting LVEF <50% was 65% and specificity was 54.05%.

Conclusion: Serum troponin I level had a strong negative correlation with left ventricular ejection fraction after acute coronary syndrome and hence can be used to predict the LVEF in this setting.

Cardiovasc. j. 2019; 12(1): 24-29

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Abstract
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Published
2019-10-03
How to Cite
Hossain, M. J., Asaduzzaman, K., Hossain, S., Alam, M. B., & Hossain, N. (2019). Study of Cardiac Troponin I level in Acute Coronary Syndrome and its correlation with Left Ventricular Systolic Function. Cardiovascular Journal, 12(1), 24-29. https://doi.org/10.3329/cardio.v12i1.43415
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Original Articles