Serum Uric Acid and Its Association with Coronary Artery Disease

  • MAK Akanda Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka
  • KN Choudhury National Centre for Control of Rheumatic fever and heart disease
  • MZ Ali National Institute of Cardiovascular Diseases
  • S Naher National Centre for Control of Rheumatic fever and heart disease
  • ASME Islam International Centre for Diarrhoeal Disease research
  • MI Ali National Institute of Cardiovascular Diseases
Keywords: Serum uric acid, Coronary artery disease, Gensini scores, Coronary angiography

Abstract

Background: Few studies have assessed the relation of uric acid level with the severity of coronary  artery disease (CAD). This study investigated the association between high uric acid levels with the  presence and severity of CAD.

Materials and Methods: This study was designed as an observational cohort study. The study was  composed of 180 patients admitted at our institution due to symptoms related to CAD. Patients  having angiographic evidence of stenosis in coronary artery were as case group and without stenosis  control group. Patients with high uric acid (hyperuricemia) were defined as serum uric acid  concentration ?7.0mg/dl or ?420 ?mol/L in men and ?6mg/dl or ?360 ? mol/L in women. The  presence of CAD has been defined as the Gensini score being ?1. 

Results: There was a statistically significant difference between the mean uric acid levels of patients  with and without CAD (358.23±71.11 ?mol/l vs251.32±54.92 ?mol/l respectively, p<0.001). There  was a statistically significant difference between ejection fraction of patients with and without CAD  (54.50±9.25 vs. 63.16±6.56 respectively, p?0.001). Spearman correlation analysis demonstrated a  positive correlation between the serum uric acid level and the severity of CAD (p=?0.001, r=0.39).  When patients were classified into four groups according to their Gensini score, mean serum uric  acid level was found to be significantly increased across the tertiles, and a statistically significant  difference was detected between the tertiles (p= ?0.001). 

Conclusion: In conclusion, a significant association has been found between serum uric acid level  and the presence and severity of CAD. In addition to the evaluation of conventional risk factors in  daily clinical practice, the measurement of uric acid level might provide significant prognostic  benefits in terms of global cardiovascular risk and management of the patients.

DOI: http://dx.doi.org/10.3329/cardio.v5i1.12206

Cardiovasc. j. 2012; 5(1): 12-17

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Abstract
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Published
2012-10-16
How to Cite
Akanda, M., Choudhury, K., Ali, M., Naher, S., Islam, A., & Ali, M. (2012). Serum Uric Acid and Its Association with Coronary Artery Disease. Cardiovascular Journal, 5(1), 12-17. https://doi.org/10.3329/cardio.v5i1.12206
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Original Articles