Anti-Inflammatory, Antioxidant and Anti-Diarrheal Effects of Ethanol Extract of Stephania Japonica

  • NU Ahmed Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong
  • R Akter Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong
  • Mohammed A Satter Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong
  • MS Khan Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong
  • F Islam Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong
  • AM Abdullah Bangladesh Council of Scientific and Industrial Research (BCSIR), Chittagong
Keywords: Anti-inflammatory, Antioxidant, Anti-diarrheal, Stephania japonica

Abstract

The present study was carried out to investigate anti-inflammatory, antioxidant and anti-diarrheal effect of ethanol extract of Stephania japonica. This study showed that the plant extract has significant (p<0.05) anti-inflammatory effect at all phases of carrageenan induced inflammation at a dose level 2g/kg. The DPPH free radical scavenging effect of the extract was compared with standard antioxidant ascorbic acid. IC50 values were found 33.57 μg/ml for the extract and 15.57 μg/ml for ascorbic acid. S. japonica extract at dosage level 2g/kg and 1g/kg decreased the gastrointestinal motility 36.56 and 21.53 %, respectively, in rats. The ethanol extract of the plant also reduced the total number of feces as well as wet feces of rats in castor oil-induced diarrheal model. The results revealed that the extract possesses promising anti-inflammatory, antioxidant and antidiarrheal activity.

Keywords: Anti-inflammatory; Antioxidant; Anti-diarrheal; Stephania japonica

DOI: http://dx.doi.org/10.3329/bjsir.v46i4.9587

BJSIR 2011; 46(4): 437-442

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How to Cite
Ahmed, N., Akter, R., Satter, M., Khan, M., Islam, F., & Abdullah, A. (1). Anti-Inflammatory, Antioxidant and Anti-Diarrheal Effects of Ethanol Extract of Stephania Japonica. Bangladesh Journal of Scientific and Industrial Research, 46(4), 437-442. https://doi.org/10.3329/bjsir.v46i4.9587
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