Microwave-assisted urea catalyzed Knoevenagel condensation of aldehydes with active methylene compounds

  • WT Purba Department of Chemistry, Shahjalal University of Science & Technology, Sylhet 3114, Bangladesh
  • PS Roy Department of Chemistry, Shahjalal University of Science & Technology, Sylhet 3114, Bangladesh
  • S Jannat Department of Chemistry, Shahjalal University of Science & Technology, Sylhet 3114, Bangladesh
  • SA Begum Department of Chemistry, Shahjalal University of Science & Technology, Sylhet 3114, Bangladesh
  • MM Rahman Department of Chemistry, Shahjalal University of Science & Technology, Sylhet 3114, Bangladesh
Keywords: Microwave; Active methylene; Green procedure; Urea catalyst; Substituted cyanoacetamide; Knoevenagel condesation

Abstract

Rapid and efficient method for the synthesis of substituted olefins such as 2-(4-chlorophenylmethylene) malononitrile, 2-(4-hydroxyphenylmethylene) malononitrile and 2-cyano-3-(4-hydroxyphenyl) acrylamide etc under the influence of microwave irradiation are described. Urea has been utilized as an efficient catalyst for the Knoevenagel condensation of aldehydes with acidic active methylene compounds such as malononitrile, ethylcyanoacetate and cyanoacetamide to afford substituted olefins under the influence of microwave irradiation. The reaction proceeds smoothly under mild and solvent free conditions and the products are obtained in good yield. The method is applicable for a wide range of aldehydes including aromatic and heterocyclic substrates.

Bangladesh J. Sci. Ind. Res.55(2), 159-164, 2020

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Abstract
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Published
2020-06-16
How to Cite
Purba, W., Roy, P., Jannat, S., Begum, S., & Rahman, M. (2020). Microwave-assisted urea catalyzed Knoevenagel condensation of aldehydes with active methylene compounds. Bangladesh Journal of Scientific and Industrial Research, 55(2), 159-164. https://doi.org/10.3329/bjsir.v55i2.47637
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Articles