Effect of ethanolic extract of Aloe vera (Aloe barbadensis) gel on blood glucose level of alloxan induced hyperglycaemic mice

  • Shammin Haque Assistant Professor, Department of Pharmacology & Therapeutics, Shaheed Suhrawardy Medical College, Dhaka
  • Ferdous Ara Assistant Professor, Department of Anatomy, OSD, Directorate General of Health Services (DGHS), Dhaka
  • Md Jalaluddin Iqbal Professor and Head, Department of Pharmacology & Therapeutics, Dhaka Medical College, Dhaka
  • Halima Begum Assistant Professor, Department of Pharmacology & Therapeutics, Faridpur Medical College, Faridpur
  • Nazmun Nahar Alam
Keywords: Ethanolic extract of Aloe vera gel, alloxan induced hyperglycaemic mice, gliclazide

Abstract

The purpose of this study was to show the antidiabetic effect of ethanolic extract of Aloe vera gel in alloxan induced hyperglycaemic mice. Ethanolic extract of Aloe vera gel was orally administered for four weeks at a dose of 300mg/kg body weight. Weekly estimates of fasting blood glucose level in normal non-diabetic and alloxan induced hyperglycaemic mice were assessed. Ethanolic Aloe vera gel extract revealed no blood glucose lowering action upon non-diabetic mice. But, a significant reduction in blood glucose level (p<0.001) was seen in diabetic mice, when compared with diabetic control. Similar results were found when compared with a standard antidiabetic drug, gliclazide. To conclude, as administration of ethanolic extract of Aloe vera gel significantly reduces blood glucose level in hyperglycaemic mice, it can optimistically emerge as a new hope in the management of diabetes mellitus.

DOI: http://dx.doi.org/10.3329/bjpp.v30i2.22680

Bangladesh J Physiol Pharmacol 2014; 30(2): 25-31

Downloads

Download data is not yet available.
Abstract
1262
PDF
1066
Published
2015-03-25
How to Cite
Haque, S., Ara, F., Iqbal, M. J., Begum, H., & Alam, N. (2015). Effect of ethanolic extract of Aloe vera (Aloe barbadensis) gel on blood glucose level of alloxan induced hyperglycaemic mice. Bangladesh Journal of Physiology and Pharmacology, 30(2), 25-31. https://doi.org/10.3329/bjpp.v30i2.22680
Section
Original Articles