Neurobehavioral assessment of seed extract of Swietenia mahagoni on zebrafish model

Authors

DOI:

https://doi.org/10.3329/bjp.v18i4.67354

Keywords:

Light-Dark Test, Mirror Bite Test, Neurobehavioral Study, Open Field Test, Predator Avoidance Test, Swietenia Mahagoni

Abstract

Traditional medicine in tropical areas often includes the use of Swietenia mahagoni to treat a wide range of conditions. However, preclinical testing is crucial to ensure their safety profile and address any remaining concerns about their efficacy.  The zebrafish model of open field test shows that decreased dopamine and cholinergic transmission causes impaired locomotion and diminished exploratory behavior. In addition to the elevation of 5-HT and GABA reported in the mirror bite test findings, the extract may have suppressed dopamine expression. The mirror-bite test and the light-dark test both showed elevated levels of GABA expression.  Findings from the predator avoidance test are very suggestive of a neurotransmitter-regulating action of the extract.

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Author Biographies

Sourav Pal, PG Institute of Medical Sciences, Dhurabila, Dhamkuria, Chandrakona Town, Paschim Medinipur 721201, West Bengal, India.

 

 

Subhajit Mandal, PG Institute of Medical Sciences, Dhurabila, Dhamkuria, Chandrakona Town, Paschim Medinipur 721201, West Bengal, India.

 

 

 

Sayed Mohammed Firdous, Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology and AHS, Uluberia, Howrah 711316, West Bengal, India.

Head of the Department

 

 

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Published

2023-12-16

How to Cite

Pal, S., S. . Mandal, and S. M. . Firdous. “Neurobehavioral Assessment of Seed Extract of Swietenia Mahagoni on Zebrafish Model”. Bangladesh Journal of Pharmacology, vol. 18, no. 4, Dec. 2023, pp. 130-7, doi:10.3329/bjp.v18i4.67354.

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Section

Research Articles