miRNA-486 and miRNA-499 in human plasma evaluate the clinical stages of lung cancer and play a role as a tumor suppressor in lung tumorigeneisis not pathogenesis





Lung cancer, Lung tumorigeneisis, miRNA-486, miRNA-499, Tumor suppressor


It was aimed to explore the expression level of miRNA-486 and miRNA-499 in the plasma of lung cancer patients and analysis their differences in expre-ssion. The expression level of both miRNA-486 and miRNA-499 in the plasma of non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) were lower than that of the control group (p<0.05) and the decrease was more obvious in NSCLC. Compare with the miRNA-499?expression quantity in NSCLC patients plasma. There was statistical significance difference (p<0.05) between III??stage and I?II stage. The expression quantity of miRNA in plasma of patients with extensive-stage SCLC was lower than that of patients with limited-stage SCLC (p<0.05). The sensitivity and specificity of plasms miRNA-486 respectively were 88.5% and 83.3%. The expression of miRNA-499 and miRNA-486 in lung cancer patients were up-regulated, and might be closely related to the occurrence and prognosis of lung cancer, and might be used as potential screening and prognosis index for lung cancer.


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How to Cite

Jia, Y., A. Zang, Y. Feng, X.-F. Li, K. Zhang, H. Li, R. Wang, Y. Wei, and R. Huo. “MiRNA-486 and MiRNA-499 in Human Plasma Evaluate the Clinical Stages of Lung Cancer and Play a Role As a Tumor Suppressor in Lung Tumorigeneisis Not Pathogenesis”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Jan. 2016, pp. 264-8, doi:10.3329/bjp.v11i1.25318.



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