Shenfu injection provides protection for perinatal asphyxia in neonates
This study aimed to investigate the efficacy of shenfu injection for the protection of neonates with asphyxia. Eighty neonates with asphyxia were randomly divided into two groups, treatment group and control group (n=40). Both groups received interventions such as ventilation, oxygen, and circulation support. Treatment group was administrated with shenfu injection additionally. Serum levels of creatine kinase, alanine aminotransferase, aspartate aminotransferase, creatinine, and neuron-specific enolase were significantly lower but the oxygenation index was significantly higher in treatment group on day 7 and day 14. The neurobehavioral score was significantly higher in treatment group than in control group. On the 14th day, the survival rate of treatment group (77.5%) was higher than that of control group (55%). Shenfu injection could protect the function of the brain, heart, lung, liver and kidney by attenuating ischemia reperfusion after severe asphyxia resuscitation, improve neurobehavioral ability and increase the survival of neonates.
Anand N1, Stead LG. Neuron-specific enolase as a marker for acute ischemic stroke: A systematic review. Cerebrovasc Dis. 2005; 20: 213-19.
Bao XL, Yu RJ, Li ZS, Zhang BL. Twenty-item behavioral neurological assessment for normal newborns in 12 cities of China. Chin Med J (Engl). 1991; 104: 742-46.
Goel N, Gupta B. Maternal risk factors affecting perinatal mortality. Indian Pediatr. 2012; 49: 188-89.
Gu W, Hou X, Zhou H, Li C. Protective effect of shenfu injection on neuronal mitochondrial function in a porcine model of prolonged cardiac arrest. Evid Based Complement Alternat Med. 2014; 2014: 523847.
Guo ZJ, Li CS. Therapeutic effects of shenfu injection on post cardiac arrest syndrome. Chin J Integr Med. 2013; 19: 716-20?
Hossmann KA. The hypoxic brain: Insights from ischemia research. Adv Exp Med Biol. 1999; 474: 155-69.
Hou X, Li C, Gu W, Guo Z, Yin W, Zhang D. Effect of shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine. Am J Emerg Med. 2013; 31: 1159-64?
Ji XF, Ji HB, Sang DY, Wang S, Yang L, Li CS. Shenfu injection reduces impaired myocardial ?-adrenergic receptor signalling after cardiopulmonary resuscitation. Chin Med J (Engl). 2013; 126: 697-702.
Leone TA, Finer NN. Shock: A common consequence of neonatal asphyxia. J Pediatr. 2011; 158 (2 Suppl): e9-12.
Wang J, Qiao LF, Yang GT. Role of shenfu injection in rats with systemic inflammatory response syndrome. Chin J Integr Med. 2008; 14: 51-55?
Yang LJ, Wang J, Tian ZF, Yuan YF. Shenfu injection attenuates neonatal hypoxic-ischemic brain damage in rat. Neurol Sci. 2013; 34: 1571-74.
Ye R, Zhang X, Kong X, Han J, Yang Q, Zhang Y, Chen Y, Li P, Liu J, Shi M, Xiong L, Zhao G. Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia. Neuroscience 2011; 178: 169-80.
Yin W, Guo Z, Li C. Comparison of epinephrine and shenfu injection on resuscitation outcomes in a porcine model of prolonged cardiac arrest. Chin Med J (Engl). 2014; 127: 724-28.
Zhang MY, Ji XF, Wang S, Li CS. Shenfu injection attenuates post-resuscitation lung injury in a porcine model of cardiac arrest. Resuscitation 2012; 83: 1152-58?
Zheng SD, Wu HJ, Yu SP, Ren JX, Duo WW, Ma ZC, Gao Y, Wang SQ, Liu YN. Shenfu injection suppresses inflammation by targeting haptoglobin and pentraxin 3 in rats with chronic ischemic heart failure. Chin J Integr Med. 2015; 21: 22-28.
Copyright (c) 2016 Yu Jiang, Rong-Rong Zhang, Li-Juan Yang, Zhen Wu, Huai-Ping Chen, Sai Zhao, Zhao-Fang Tian
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