Shenfu injection provides protection for perinatal asphyxia in neonates

Authors

  • Yu Jiang Department of Pediatrics, Huai'an Hospital Affiliated to Xuzhou Medical College and Huai'an Second People's Hospital, Huai?an, 223300
  • Rong-Rong Zhang Department of Neonatology, Huai?an First Hospital Affiliated to Nanjing Medical University, Huai?an, 223300 http://orcid.org/0000-0001-5736-2617
  • Li-Juan Yang Department of Neonatology, Huai?an First Hospital Affiliated to Nanjing Medical University, Huai?an, 223300
  • Zhen Wu Department of Neonatology, Huai?an First Hospital Affiliated to Nanjing Medical University, Huai?an, 223300
  • Huai-Ping Chen Department of Neonatology, Huai?an First Hospital Affiliated to Nanjing Medical University, Huai?an, 223300
  • Sai Zhao Department of Neonatology, Huai?an First Hospital Affiliated to Nanjing Medical University, Huai?an, 223300
  • Zhao-Fang Tian Department of Neonatology, Huai?an First Hospital Affiliated to Nanjing Medical University, Huai?an, 223300

DOI:

https://doi.org/10.3329/bjp.v11i1.25124

Keywords:

Neonate, Perinatal asphyxia, Shenfu

Abstract

This study aimed to investigate the efficacy of shenfu injection for the protection of neonates with asphyxia. Eighty neonates with asphyxia were randomly divided into two groups, treatment group and control group (n=40). Both groups received interventions such as ventilation, oxygen, and circulation support. Treatment group was administrated with shenfu injection additionally. Serum levels of creatine kinase, alanine aminotransferase, aspartate aminotransferase, creatinine, and neuron-specific enolase were significantly lower but the oxygenation index was significantly higher in treatment group on day 7 and day 14. The neurobehavioral score was significantly higher in treatment group than in control group. On the 14th day, the survival rate of treatment group (77.5%) was higher than that of control group (55%). Shenfu injection could protect the function of the brain, heart, lung, liver and kidney by attenuating ischemia reperfusion after severe asphyxia resuscitation, improve neurobehavioral ability and increase the survival of neonates.

 

Downloads

Download data is not yet available.
Abstract
1765
Download
780 Read
474

References

Anand N1, Stead LG. Neuron-specific enolase as a marker for acute ischemic stroke: A systematic review. Cerebrovasc Dis. 2005; 20: 213-19.

Bao XL, Yu RJ, Li ZS, Zhang BL. Twenty-item behavioral neurological assessment for normal newborns in 12 cities of China. Chin Med J (Engl). 1991; 104: 742-46.

Goel N, Gupta B. Maternal risk factors affecting perinatal mortality. Indian Pediatr. 2012; 49: 188-89.

Gu W, Hou X, Zhou H, Li C. Protective effect of shenfu injection on neuronal mitochondrial function in a porcine model of prolonged cardiac arrest. Evid Based Complement Alternat Med. 2014; 2014: 523847.

Guo ZJ, Li CS. Therapeutic effects of shenfu injection on post cardiac arrest syndrome. Chin J Integr Med. 2013; 19: 716-20?

Hossmann KA. The hypoxic brain: Insights from ischemia research. Adv Exp Med Biol. 1999; 474: 155-69.

Hou X, Li C, Gu W, Guo Z, Yin W, Zhang D. Effect of shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine. Am J Emerg Med. 2013; 31: 1159-64?

Ji XF, Ji HB, Sang DY, Wang S, Yang L, Li CS. Shenfu injection reduces impaired myocardial ?-adrenergic receptor signalling after cardiopulmonary resuscitation. Chin Med J (Engl). 2013; 126: 697-702.

Leone TA, Finer NN. Shock: A common consequence of neonatal asphyxia. J Pediatr. 2011; 158 (2 Suppl): e9-12.

Wang J, Qiao LF, Yang GT. Role of shenfu injection in rats with systemic inflammatory response syndrome. Chin J Integr Med. 2008; 14: 51-55?

Yang LJ, Wang J, Tian ZF, Yuan YF. Shenfu injection attenuates neonatal hypoxic-ischemic brain damage in rat. Neurol Sci. 2013; 34: 1571-74.

Ye R, Zhang X, Kong X, Han J, Yang Q, Zhang Y, Chen Y, Li P, Liu J, Shi M, Xiong L, Zhao G. Ginsenoside Rd attenuates mitochondrial dysfunction and sequential apoptosis after transient focal ischemia. Neuroscience 2011; 178: 169-80.

Yin W, Guo Z, Li C. Comparison of epinephrine and shenfu injection on resuscitation outcomes in a porcine model of prolonged cardiac arrest. Chin Med J (Engl). 2014; 127: 724-28.

Zhang MY, Ji XF, Wang S, Li CS. Shenfu injection attenuates post-resuscitation lung injury in a porcine model of cardiac arrest. Resuscitation 2012; 83: 1152-58?

Zheng SD, Wu HJ, Yu SP, Ren JX, Duo WW, Ma ZC, Gao Y, Wang SQ, Liu YN. Shenfu injection suppresses inflammation by targeting haptoglobin and pentraxin 3 in rats with chronic ischemic heart failure. Chin J Integr Med. 2015; 21: 22-28.

Downloads

Additional Files

Published

2016-01-25

How to Cite

Jiang, Y., R.-R. Zhang, L.-J. Yang, Z. Wu, H.-P. Chen, S. Zhao, and Z.-F. Tian. “Shenfu Injection Provides Protection for perinatal asphyxia in Neonates”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Jan. 2016, pp. 236-9, doi:10.3329/bjp.v11i1.25124.

Issue

Vol. 11 No. 1 (2016)

Section

Research Articles

License

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).