Cardioprotective activity of fruit of Garcinia pedunculata on isoprenaline-induced myocardial infarction in rat

Authors

  • Ravi Mundugaru Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi 574118
  • Padmaja Udaykumar Department of Pharmacology Father Muller Medical College, Mangalore 575 002
  • Sivanesan Senthilkumar Department of Research and Development, Saveetha University, Thandalam, Chennai 602105
  • Sudhakara Bhat Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi 574118

DOI:

https://doi.org/10.3329/bjp.v11i1.24941

Keywords:

Cardioprotective, Garcinia pedunculata, Isoprenaline, Myocardial infarction

Abstract

The present study reveals the protective effect of Garcinia pedunculata aqueous fruit extract in isoprenaline-induced myocardial infarction in Wistar rats. Isoprenaline (200 mg/kg) administration subcutaneous once daily for two consecutive days significantly (p<0.01) increased the CK-MB, AST, ALT, ALP activity and CRP (p<0.05) levels. Pretreatment with extract (400 mg/kg) orally for 14 consecutive days significantly ameliorated the effect of isoprenaline by reducing the activity of CK-MB and the levels of ALP, SGPT respectively. No significant changes were seen in the case of SGOT activity and CRP levels. Severe necrotic lesions in the myocardial tissue were observed in isoprenaline-treated group. In extract-treated group, mild degenerative changes of myo-cardial tissues to nearly normal cytoarchitecture were seen. The results indicate the cardioprotective effect of G. pedunculata against isoprenaline- induced myocardial infarction rat model.

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Author Biographies

Ravi Mundugaru, Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi 574118

Research Officer

Padmaja Udaykumar, Department of Pharmacology Father Muller Medical College, Mangalore 575 002

Professor  & Head

Sivanesan Senthilkumar, Department of Research and Development, Saveetha University, Thandalam, Chennai 602105

Professor

Sudhakara Bhat, Department of Pharmacology and Toxicology, SDM Centre for Research in Ayurveda and Allied Sciences, Udupi 574118

Research Officer

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Published

2016-01-24

How to Cite

Mundugaru, R., P. Udaykumar, S. Senthilkumar, and S. Bhat. “Cardioprotective Activity of Fruit of Garcinia Pedunculata on Isoprenaline-Induced Myocardial Infarction in Rat”. Bangladesh Journal of Pharmacology, vol. 11, no. 1, Jan. 2016, pp. 231-5, doi:10.3329/bjp.v11i1.24941.

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Section

Research Articles