Synthesis, characterization, and anti-plasmodial activity of 2,6-substituted benzothiazole derivatives

Authors

  • Gnanavel Sadhasivam Department of Chemistry, Government College of Engineering, Salem 636011, Tamil Nadu http://orcid.org/0000-0002-2771-4279
  • Kannan Kulanthai Department of Chemistry, Government College of Engineering, Salem 636011, Tamil Nadu
  • Sowmiya Rajamani Department of Biotechnology, School of Bioscience, Periyar University, Salem 636011, Tamil Nadu
  • Pachiappan Perumal Department of Biotechnology, School of Bioscience, Periyar University, Salem 636011, Tamil Nadu

DOI:

https://doi.org/10.3329/bjp.v11i2.24886

Keywords:

Anti-plasmodial, Benzothiazole, Synthesis

Abstract

Six compounds of benzothiazole derivatives were synthesized, and structures were confirmed by FT-IR, 1H-NMR, 13C-NMR and LC-MS. The resulting compounds were evaluated for anti-plasmodial activity against Plasmodium falciparum by Giemsa stain. Among them the compounds 3b and 4 showed potent anti-plasmodial activity against P. falciparum. The compounds 3a, 5a, 5b also showed moderate anti-plasmodial activity. The structure-activity relationships of benzothiazole derivatives also discussed which were useful for exploring and developing benzothiazole derivatives as novel anti-malarial drugs.

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Published

2016-03-17

How to Cite

Sadhasivam, G., K. Kulanthai, S. Rajamani, and P. Perumal. “Synthesis, Characterization, and Anti-Plasmodial Activity of 2,6-Substituted Benzothiazole Derivatives”. Bangladesh Journal of Pharmacology, vol. 11, no. 2, Mar. 2016, pp. 321-7, doi:10.3329/bjp.v11i2.24886.

Issue

Section

Research Articles